On February 28, according to the New England Journal of Medicine**, an AIDS patient known as the "City of Hope Patient" stopped anti-AIDS drugs after receiving a successful CCR5 Delta 32 stem cell transplant from a donor, and in the following four years, no active HIV virus was detected in the patient's body, and the "City of Hope Patient" officially became the fifth confirmed case of HIV** in the world! From the announcement of the London patient in 2020 to this year, four patients have been declared successful**, and the City of Hope patient is the oldest of the AIDS patients announced**, and the sixth "Geneva patient" has become a special case of long-term remission of AIDS, which is expected to provide new ideas for AIDS!
The New England Journal of Medicine officially announced that the fifth AIDS patient to be ** - "City of Hope Patient" Paul Edmonds, who is 68 years old this year, was diagnosed with AIDS in 1988 and has been receiving antiretroviral** for many years to suppress the HIV virus.
In 2018, Edmund was diagnosed with acute myeloid leukemia and began preparing for a bone marrow transplant while undergoing chemotherapy with a donor who had a rare CCR5 delta 32 mutation gene.
In 2021, Edmund decided to stop taking drugs that suppress AIDS, and after three years of close monitoring, Edmund no longer had any trace of HIV in his body, and in February this year, 5 years after Edmund's bone marrow transplant, he officially became the fifth person in the world to be AIDS **!
In the last two years, a number of AIDS patients have been announced**, and last year the "Düsseldorf patient" announced**, a patient who was mainly treated in the hospital in Düsseldorf, Germany**, and was diagnosed with the same acute myeloid leukemia in 2011. In 2013, he received a stem cell transplant from a female donor who also had the CCR5 delta 32 mutation gene.
After the operation, the patient continued to receive antiretroviral**, discontinued antiretroviral** in 2020, and also did not detect active HIV for four years thereafter, in order of the corresponding **publication time, he was the third person to be successfully **.
The world's first person to be ** HIV infected is the "Berlin patient" Timothy Ray Brown (Timothy Ray Brown), born in 1966, in 1995, he was diagnosed with HIV while studying in Berlin, in 2006, he underwent a bone marrow transplant to ** acute myeloid leukemia, the donor also has a rare genetic mutation in his body, which also makes him naturally resistant to HIV, in 2010, Brown announced the news of his **, Shocked the world, Brown died of leukemia** in 2020.
The second "London patient", Adam Castillejo, was born in Venezuela in 1982, moved to London, England in 2002, was diagnosed with HIV the following year, was diagnosed with Hodgkin lymphoma in 2012, received a bone marrow transplant in 2016, his donor also has a CCR5 gene mutation in his body, and in 2020 Castillejo announced**, he is still alive and healthy, and continues to contribute to the cause of **AIDS**.
In a total of five cases of AIDS, the CCR5δ32 mutation gene became the key, and the δ32 mutation refers to the deletion of 32 base pairs in the CCR5 gene, which disrupts the normal function of the CCR5 receptor and makes it difficult for HIV to bind to it and enter the cell.
As a result, individuals with the CCR5δ32 mutation are highly resistant to HIV infection, and the discovery of the CCR5δ32 mutation is a major breakthrough in HIV research, which is currently only available in about 1% of people in Europe, and researchers are developing drugs that mimic the effects of the CCR5δ32 mutation by blocking the CCR5 receptor to prevent HIV infection, or to slow the disease of people living with HIV.
In addition, in fact, there was a man called "Geneva Patient" last year, he received a stem cell transplant from a donor who did not carry the CCR5 mutation, but the AIDS condition has also been in long-term remission, and the possibility of the man** has not been completely ruled out, but researchers generally believe that he has been in a long-term remission, which also provides a new idea for the **AIDS **.