This article is from "Nankai Sun Pharmacist", which is used for medical science popularization for reference. Magnesium aluminum carbonate is an antacid, oral can quickly neutralize gastric acid, relieve stomach pain, acid reflux, heartburn, fullness, belching and other gastric acid-related gastric discomfort symptoms, in addition, aluminum magnesium carbonate is also a gastric mucosal protective agent, can promote prostaglandin synthesis, increase mucosal blood flow, enhance the role of gastric mucosal protective factors, and can combine bile acid, continue to prevent pepsin and bile acid damage to the stomach, promote faster and better healing of lesions, in clinical use for ** gastric and duodenal ulcer, acute, Chronic gastritis, reflux esophagitis, bile reflux gastritis and other digestive diseases.
Colloidal pectin bismuth is a kind of gastric mucosal protector, which can form a stable colloid in the gastric acid environment, adhere to the surface of the gastric mucosa, block the self-digestion of gastric acid and pepsin on the mucosa, promote the repair and healing of diseased tissues, and can stimulate the synthesis of prostaglandins and epidermal growth factors, accelerate the healing of ulcer surface and the resolution of inflammation, and have a certain hemostatic effect. In addition, colloidal pectin bismuth can also wrap Helicobacter pylori bacteria, interfere with Helicobacter pylori metabolism, has the effect of killing Helicobacter pylori, and is mainly used in clinical use for gastric and duodenal ulcers, chronic gastritis, and can be combined with antibiotics for Helicobacter pylori to improve the rate.
Rebamipide is also a gastric mucosal protector, which can protect the gastric mucosa, increase the blood flow of the gastric mucosa, promote the regeneration of gastric mucosal cells, repair the damaged gastric mucosa, promote ulcer healing, and has anti-inflammatory effects, and is mainly used in clinical practice for gastric ulcers and acute and chronic gastritis.
These three drugs are gastric mucosal protectors, aluminum magnesium carbonate can not only neutralize gastric acid, relieve acid-related gastric discomfort, but also protect the gastric mucosa, neutralize bile acids, its effect is more comprehensive, the range of use is more extensive, can be chewed after meals, can also be chewed before bed or stomach discomfort, medication time is more flexible, medication compliance is better. The advantage of gastric mucosal protectors such as colloidal pectin bismuth is that they can kill Helicobacter pylori and help improve the rate of Helicobacter pylori, but the pain-relieving effect on stomach pain is relatively slow. There are few data on human clinical trials of rebamipide, and the efficacy is not clear enough.
In terms of safety, aluminum magnesium carbonate and colloidal pectin bismuth have a large molecular weight, and are almost not absorbed in the gastrointestinal tract after oral administration, and aluminum magnesium carbonate occasionally has adverse reactions such as constipation, dry mouth, and loss of appetite. Rebamipide can see nausea, vomiting, heartburn, acid reflux, belching, abdominal pain, diarrhea and other gastrointestinal reactions, of which the most reported is diarrhea, and can cause abnormal liver function and serious adverse reactions such as leukocyte and thrombocytopenia, once found, the administration should be stopped immediately, therefore, in comparison, the safety of aluminum magnesium carbonate and colloidal pectin bismuth is better, but it should be noted that long-term use of colloidal pectin bismuth may cause bismuth to accumulate in the body, causing bismuth poisoning, bismuth is a metallic substance, A large amount of bismuth can be deposited in the brain and kidneys, a large amount of deposition in the brain tissue will cause headaches, insomnia, poor memory, mental abnormalities, a large amount of deposition in the kidneys will cause renal function decline, and eventually lead to uremia, therefore, it is recommended that colloidal pectin bismuth ** course of treatment should not exceed 8 weeks, ** in the process of memory loss, mental abnormalities, urine output decrease, should be vigilant bismuth poisoning, as soon as possible to the hospital for examination.