Will the genes be contaminated or tampered with when the allogeneic stem cells are transfused?

Mondo Health Updated on 2024-02-26

Recently, some fans asked: stem cells are called pluripotent cells, and they can also be turned into other cells, so if the allogeneic stem cells are infused, will the genes be contaminated or tampered with?

In fact, this concern is indeed a bit taken for granted, and the reason why many genetic defects and diseases have become medical problems is because genes are indeed difficult to change. You must know that our human genes are not formed in a day or two, nor do they fall from the sky, but are formed and accumulated by the ancestors of animals and plants from generation to generation in the process of survival and development, and I don't know how many years have gone through during this period.

In each generation, we may change some genes due to some life experiences (lifestyle, environmental factors, etc.), but the changes are very small, and the differences will gradually become apparent only after being passed on from generation to generation.

Let's talk about the possibility of changing genes:

First of all, we must first determine that the reinfused is a living cell, because genes exist inside the cell, and most of our own genes are in the nucleus, foreign DNA must first enter the cytoplasm after entering the cell, and the substance of dissolving DNA is in the cytoplasm, and it is an extremely complex biological process to enter itTherefore, the chance of one's own genome being tampered with by foreign cells is very small.

Furthermore, after stem cells enter the human body, will the genes conflict?

At present, in the clinical research of stem cells, the most involved category is mesenchymal stem cells, mesenchymal stem cells have a characteristic called low immunogenicity, so there is no rejection reaction, and immune cells will not kill mesenchymal stem cells. And it is worth noting thatWhen the mesenchymal stem cells complete their mission, they will be gradually replaced by new endogenous tissue cells and will not remain in the body for a long time, so there is no need to worry about gene conflicts

Through the above, I believe you should understand that our genes will not be contaminated or tampered with by transfusion of allogeneic stem cells. Stem cells or immune cells**

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