Products that produce dust or use harmful, flammable and explosive raw materials in the production process of cosmetics must be produced in a separate workshop. The total area of production, filling and packaging room shall not be less than 100 square meters, the per capita floor area shall not be less than 4 square meters, and the net height of the workshop shall not be less than 25 meters.
One of the most important aspects of microbial contamination of cosmetics is the air environment, so the purification level of the air in the workshop should be controlled according to the requirements of the production process and product quality. In the cosmetics production environment, the air in the cosmetics filling workshop must be designed in accordance with GMP requirements, and the number of aseptic colonies should not exceed one. Efficient and broad-spectrum sterilization methods should be selected in the dust-free workshop, and there are many sterilization methods that can be selected, such as ultraviolet irradiation, drug sterilization and filtration sterilization. However, each sterilization method must have a highly effective sterilization capacity. Low toxicity or non-toxicity, safe and reliable. The operation process is convenient, etc. The air filtration of the dust-free workshop is very important, mainly used for the air purification of the production workshop with high purification requirements, which requires filtration equipment, and ethylene oxide and formaldehyde are commonly used for drug sterilization. When sterilizing with these two gases, it is necessary to pay attention to its ** limit and allowable concentration, ultraviolet light has a strong bactericidal effect, simple installation, easy to use, and is widely used at present.
In addition to the air environment, microbial contamination in the cosmetics production process may also be affected by raw materials, operators, equipment and other aspects. Therefore, in order to control microbial contamination, other measures need to be taken in addition to purifying the air in the workshop.
First of all, the quality and storage conditions of raw materials should be strictly controlled to ensure that the raw materials are sterile and dust-free, and to avoid the breeding of microorganisms. For some raw materials that are easily contaminated, they can be sterilized by adding preservatives or disinfectants. Secondly, the operator is an important link in the production of cosmetics, and it is also one of the main sources of microbial contamination. Therefore, operators must undergo strict training and assessment, master the control methods of microbial contamination, comply with hygiene regulations, and maintain good personal hygiene habits. In addition, equipment is also one of the most important microorganisms in the production of cosmetics. The cleaning and maintenance of equipment is an important measure to control microbial contamination. Production equipment should be cleaned, disinfected and maintained regularly to ensure the sterility of the equipment. In summary, controlling microbial contamination in the cosmetics production process needs to start from many aspects, including air purification, raw material control, personnel management and equipment maintenance. Only by taking comprehensive measures can the safety and effectiveness of cosmetics be guaranteed.