The Chinese New Year is approaching, relatives and friends gather to eat, and it is inevitable to push the cup and change the lamp. And if you or your family and friends happen to be taking medicine, be careful: taking medicine and drinking alcohol are not worthy at all. Especially if you are taking the medicines mentioned in this article, you should not drink alcohol! Today (February 8), Jiangsu CDC conducted authoritative science popularization.
1. Most cephalosporins contain a methiotetrazole group similar to the chemical structure of disulfiram, which may cause disulfiram-like reactions if you drink alcohol before and after taking the drug. Disulfiram-like reaction refers to the fact that some drugs have a similar chemical structure to disulfiram, and if you drink alcohol after taking the drug, you may experience facial flushing, conjunctival hyperemia, blurred vision, violent throbbing of blood vessels in the head and neck or throbbing headache, dizziness, nausea, vomiting, dyspnea, convulsions, and even death. Once a disulfiram-like reaction occurs, the drug and alcohol-containing products should be stopped in time, and the mild cases can be relieved on their own, and the more severe ones need to be sent to the hospital for oxygen inhalation and symptomatic treatment**.
It is especially reminded that cephalosporins should not be taken within 3 days after drinking. Do not drink alcohol within 7 days of medication, and prohibit drugs and foods containing alcohol, such as eating wine chocolate, taking Huoxiang Zhengqi Water, using injections containing ethanol as excipients, and using alcohol treatment**. In addition, nitidazoles, such as metronidazole and tinidazole, may also react disulfiram-like with ethanol and should be used separately.
2. Acetaminophen tablets are used to reduce fever in most cold medicines, and are also commonly used to relieve mild to moderate pain (such as joint pain, migraine, etc.). Studies have shown that alcohol consumption may increase acetaminophen liver toxicity.
3. Excessive alcohol consumption has the effect of dilating blood vessels, inhibiting sympathetic nerves and vascular motor centers, and weakening myocardial contractility. If you take antihypertensive drugs after drinking, the small blood vessels will be more dilated, the blood volume will be further reduced, the blood pressure will drop sharply, and orthostatic hypotension or syncope will occur.
4. There is a pharmacokinetic interaction and certain pharmacodynamic interaction between aspirin and ethanol. Intake of ethanol at any concentration will increase irritation of the digestive tract, cause gastric mucosal lesions or ulcers**, and increase the risk of upper gastrointestinal bleeding associated with aspirin.
5. After the combination of sedative-hypnotic drugs and ethanol, the degree of inhibition of the center is related to the type of drug, dosage and alcohol consumption, which is manifested as aggravation of drowsiness, reduced response sensitivity, distraction, poor coordination, and even death.
6. Ethanol can affect the metabolism of some antiepileptic drugs, thereby affecting the efficacy. In addition, drinking alcohol itself can also cause seizures. Therefore, people with epilepsy are not suitable for drinking.
7. Drinking alcohol while taking sulfonylureas can cause severe hypoglycemia or irreversible neurological lesions. Because ethanol can lower blood sugar by blocking the conversion of glycerol, lactic acid, and certain amino acids into sugar, it can also cause a "disulfiram-like reaction".
In conclusion, ethanol can alter the response of many drugs, and heavy alcohol consumption can affect the biotransformation of many drugs. You should read the instructions carefully while taking the drug, and inform the doctor of your recent drinking history when you see a doctor. Alcohol should be avoided during the administration of the above drugs to avoid serious adverse reactions.
If someone remembers that they have taken their medicine after drinking, remember to closely monitor themselves for any symptoms and if they do, be sure to go to the hospital or call 120.
Zero Distance" reporter Liu Shu correspondent Su CDC editor Guozheng).