On February 3, the Chongqing ** reporter learned from the First Affiliated Hospital of Heavy Medical Sciences that the team of Professor Cao Ju, deputy director of the medical laboratory department of the hospital, found that bone morphogenetic protein 9 (BMP9) is a new biomarker for the prognosis evaluation of sepsis patients, and it is also the target of the host-oriented **, providing an important theoretical and immune target for the precision of sepsis based on biomarkers. The results of the study were recently published in the international authoritative journal of translational medicine, Science Translational Medicine, entitled "Bone morphogenetic protein 9 is a candidate prognostic biomarker and host-directed ** target for sepsis".
*Partial screenshots. Photo courtesy of the interviewee.
Sepsis is known to be the leading cause of death in severely ill patients, with a mortality rate of 20%-40%. According to the latest global burden of disease statistics, sepsis affects about 50 million people each year, and sepsis is caused by 1 in 5 deaths worldwide.
Clinically, bacterial infections of the respiratory and gastrointestinal systems are the most common and important causes of sepsis. Cao Ju said that the pathogenesis of sepsis is based on the inability of the host immune system to control the infection, which in turn induces a multi-system inflammatory response and multi-organ failure, which ultimately leads to the death of patients. To date, none of the drugs that are effective in reducing sepsis mortality have been conclusively demonstrated in clinical practice.
Through large-sample clinical studies, we found that the lower the serum BMP9 concentration, the worse the prognosis of sepsis patients, which can be used as a new biomarker for early risk warning. Cao Ju introduced that he and his team further established a mouse sepsis model induced by multiple bacterial infections in the lungs and abdominal cavity, and confirmed that BMP9 supplementation can exert an immune effect on sepsis mice.
BMP9 promotes macrophage recruitment and phagocytosis. Information**.
It is reported that the research has been supported by projects such as the National Natural Science Project, the Chongqing Natural Science Center, the Chongqing Young and Middle-aged Medical Excellence Team, the Major Scientific and Technological Talent Project of Chongqing Medical University, and the Discipline Improvement Program of the First Affiliated Hospital of Heavy Medicine.