Article 1986Brain Science**
February 1, 2023day
Science Times
nature medicineļ¼Is Alzheimer's disease contagious? The mechanism is similar to that of mad cow disease
*: WuXi AppTec.
In general, Alzheimer's disease can be divided into two types: late-onset and early-onset. These patients are usually due to mutations in specific genes associated with amyloid(a) production, resulting in patients who may begin to develop symptoms of the disease as early as the age of 30 to 40.
Recently, a research and development team from the United Kingdom found that in rare cases, Alzheimer's disease also exhibits the characteristics of prion disease (prion disease), which may be transmitted to individuals receiving ** through biological products derived from the human brain. The researchers noted that this finding has important implications for the pathogenesis and potential strategies of Alzheimer's disease.
Nat Commun: When does the brain grow? The new findings shocked neuroscientists
*: Biocom.
It is generally accepted that the brain of mice develops faster than other longer-lived mammals, such as primates and humans, because of its shorter overall developmental lifespan. However, a recent study at Argonne National Laboratory found that although mice and primates have different lifespans, their brain synapses develop at the same rate.
Mice typically live for 2 years and monkeys have a lifespan of 25 years, but their brains develop synapses at the same time. In addition, comparing the brains of adult mice with those of adult primates, it was found that primate neurons had far fewer connections than mouse neurons.
BMJ: People with OCD have a higher risk of dying
*: Biological world.
Obsessive-compulsive disorder (OCD) is a common long-term mental disorder that affects about 2% of the world's population. Past research on the causes of death in OCD has focused on unnatural causes (e.g., suicide), and little is known about specific natural causes. Recently, a large-scale study conducted by researchers at the Karolinska Institute showed that people with OCD may be more likely to die from natural and unnatural causes than those without the disorder.
After adjusting for a range of potential influencing factors, including year of birth, gender, country, immigration status, education, and household income, the risk of all-cause mortality increased by 82% in people with OCD. Among them, the risk of natural death increased by 31%, and the risk of unnatural death increased by 3 times.
ACS nano: a zinc-organic framework-based multifunctional AIE nanozyme to facilitate recovery from spinal cord injury
*: Theory of Strange Things.
Achieving functional recovery after spinal cord injury (SCI) is a challenging challenge. Traditional medicines** focus on suppressing the immune response. However, strategies to alleviate oxidative stress are still lacking. To this end, researcher Liao Yuhui of Southern Medical University, Academician Tang Benzhong and Professor Zhao Zheng of Chinese University of Hong Kong (Shenzhen) and Professor Ji Zhisheng of Jinan University have developed aggregation-induced luminescence (AIE) nanoenzymes based on zinc-organic frameworks (zn@mof) and used them to accelerate recovery after SCI. The study found that these nanozymes were able to gradually release gallic acid and zinc ions at the SCI location. The released gallic acid is a reactive oxygen species (ROS) scavenger that promotes antioxidants and reduces inflammation, thereby re-establishing the balance between ROS production and the antioxidant defense system.
alzheimer'S & Dementia: Trends in the prevalence of cognitive impairment in the elderly in China, 2002-2018
*ļ¼bioartmed
A recently published study analysed six longitudinal surveys of healthy longevity in China (CLHLS) from 2002 to 2018, covering more than 44,000 people aged 65 to 105.7More than 20,000 observations. The study used the Generalized Estimation Equation (GEE) to investigate the prevalence of cognitive impairment (CI) and its related trends among older adults in China over a 16-year period. The results of the study showed that the prevalence of CI in the elderly in China showed a clear nonlinear trajectory. The age-standardized prevalence initially rose dramatically between 2002 and 2008, reaching 28The peak peaked at 2% and gradually decreased in subsequent years. This pours"u "The model challenges previous assumptions and emphasizes the dynamic nature of cognitive health in older populations.
Clinical Psychology Review: What Really Are People Thinking About Self-Harm Without Suicidal Injury?
*: Lei Li and the students.
More than 700,000 people die by suicide every year globally, and the suicide rate is rising. Nonsuicidal self-injury (NSSI) is more prevalent, accounting for 4 to 5 of the cases9% and 15-18% for adolescents. A recent study reviewed the content and characteristics of suicide and NSSI mental imagery, the association between mental imagery and behavior, and the intervention of suicide and NSSI psychological imagery. It was found that there was a positive association between suicidality or NSSI mental imagery and suicidality or NSSI behavior. Mental imagery intervention based on positive autobiographical memory can reduce suicidal ideation, while functional imagery training has no obvious effect on NSSI behavioral intervention.
Current Biology: These male marsupials give up sleep in order to mate
*: CellPress Cell Science.
Lack of sleep in humans or animals can cause difficulty concentrating, irritability, and other adverse effects. However, in a recent surprise, a small Australian marsupial called the Broad-footed Quoll, sacrifices several hours of sleep per night during mating season to have more time for mating.
The years-long study is the first to give direct evidence of such sleep restriction in land mammals, the researchers said. They say it's a trade-off between sleep and reproduction, and may be driven by intense sexual selection.
Max Planck Institute Symposium: A number of scholars criticized the new research that "nature's remote team does not subvert".
*: Chichi Club.
According to the post innatureIf researchers can collaborate in the field, there is a greater likelihood of achieving breakthrough results. This is due to the fact that remote teams spend less time generating innovative ideas, fewer people participate in the overall research process, and the contribution of new researchers is relatively limited. However, at a recent special symposium held by Max Planck in Germany, researchers from various European units believed that this measurement method was quite inadequate, and criticized the conclusions of the study. Scholars put forward their views from various perspectives, such as the measurement method of the disruptive index, the evaluation of research results, the importance of on-site teams, the challenges faced by remote teams, and whether major breakthroughs in the past will affect future innovation.
Reviewer: Simon