Lyp-1 (cgnkrtrgc) in LYP-1-PEG2000-DSPE is a small targeted peptide that has been found to have properties to target tumors and their microenvironment. LYP-1 achieves its targeting effect mainly through the following mechanisms:
Targeting tumor-associated lymphatic vessels:
LYP-1 has been found to specifically target certain types of tumor cells and tumor-associated lymphatic vessels. Lymphatic vessels are an important pathway for tumor spread and metastasis. By targeting these structures, LYP-1 can help diagnose and ** tumors.
Intracellular delivery:
LYP-1 contains sequences that are able to permeate cell membranes, which allows it to be used as a drug delivery system to deliver ** agents directly into tumor cells or tumor microenvironments.
Inhibition of tumor growth and metastasis:
Studies have found that LYP-1 can not only target tumors, but also inhibit tumor growth and metastasis by interfering with the growth and invasion process of tumor cells.
Promote apoptosis of tumor cells:
LYP-1 has also been found to induce apoptosis in tumor cells, which is achieved by activating specific cell signaling pathways.
Enhance drug permeability:
LYP-1 can enhance the permeability and accumulation of the drug in tumor tissues, thereby improving the ** effect.
Imaging markers:
Due to its targeted properties, LYP-1 is also used in tumor imaging to help doctors localize tumors and monitor** effects.
DSPE-PEG-MPG can be integrated into more complex drug delivery systems, such as liposomes, nanoparticles, or polymers. These systems combine the specificity of the targeted peptide with the unique properties of other materials, such as increased stability, increased drug load, or controlled release.