Professor Jiang Xingyu of Southern University of Science and Technology & Professor Long Yunze of Qingdao University: An in-situ dressing containing multi-arm antibiotics for irregular wounds
Background:
Acute and infectious wounds resulting from accidents, battlefield trauma, or surgical interventions have become a global healthcare burden due to the complex environment of bacterial infection. Conventional gauze dressings do not have sufficient contact with irregular wounds and lack antimicrobial activity against multidrug-resistant bacteria. Therefore, Prof. Xingyu Jiang of Southern University of Science and Technology & Prof. Yunze Long of Qingdao University have developed an in-situ nanofiber dressing that can fit wounds of various shapes and sizes, while providing nanoscale comfort and excellent antimicrobial properties. The research results were published in the journal Aggregate under the title "An in Situ dressing material containing a multi-armed antibiotic for healing irregular wounds".
Innovation:
1.Development of an in-situ nanofiber dressing: By using a hand-held electrospinning device, an in-situ nanofiber dressing was developed that can be deposited directly onto specific irregular wound sites to achieve perfect wound closure and be completed in less than 2 minutes, avoiding the problem of mismatch between traditional dressings and wounds.
2.Application of multi-arm antibiotics: Loading a multi-arm antibiotic (E-4PBA) into a nanofiber dressing exhibited excellent antimicrobial activity against Staphylococcus aureus (S. aureusAureus) and methicillin-resistant Staphylococcus aureus (MRSA) have excellent antimicrobial properties. Compared to conventional vancomycin, this in-situ nanofiber dressing exhibits good antimicrobial properties against up to 98% of multidrug-resistant bacteria.
3.Biocompatibility: This dressing has excellent biocompatibility and favors the growth and proliferation of cells.
4.In vivo results: Experiments in animal models have shown that wounds infected with this in situ nanofiber dressing** significantly accelerate wound healing faster than conventional dressings.
Problem solved:
1.Treatment of irregular wounds: Traditional dressings often fail to fit irregular wounds completely, resulting in incomplete wound closure and susceptibility to infection. The in-situ nanofiber dressing developed in this study can be directly deposited on the irregular wound site to achieve perfect wound closure and avoid the problem of mismatch between traditional dressings and wounds.
2.Multidrug-resistant bacterial infections: With the prevalence of multidrug-resistant bacteria, traditional dressings have limited antimicrobial ability against these bacteria. The multi-arm antibiotic-loaded in situ nanofiber dressing used in this study has excellent antimicrobial properties against multidrug-resistant bacteria and can effectively prevent infection.
3.Biocompatibility: The biocompatibility of the dressing is an important factor to consider during use, and this study verified that the dressing has excellent biocompatibility, which is beneficial for cell growth and proliferation.
4.Wound healing speed: Wounds infected with this in-situ nanofiber dressing** have been shown to significantly accelerate wound healing faster than conventional dressings.
As a result, the study provides new solutions to emergency, accident and surgical healthcare**, addressing clinical issues such as irregular wound management, multidrug-resistant bacterial infections and speed of wound healing.
Scheme 1: Schematic diagram of a personalized nanofiber dressing for wound healing.
Figure 1: Preparation and characterization of personalized nanofiber dressings.
Figure 2: Concept and characterization of antimicrobial activity of in-situ electrospun nanofiber dressings.
Figure 3: In vitro biocompatibility evaluation of personalized nanofiber dressings.
Figure 4: In vivo healing properties of nanofiber dressings in a model of infected wounds.
Figure 5: Histological evaluation of the site of infection during wound healing.
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