In recent years, there have been more and more patients with gastric diseases in China, such as gastric ulcers, gastric mucosal erosion, upper gastrointestinal bleeding, etc.
Because of the increase in the number of patients with stomach problems, drugs for stomach diseases such as omeprazole have become more and more popular. However, many people don't know that omeprazole is listed as a key monitoring drug and cannot be abused! Not recently, Mr. Wu was admitted to the hospital for abusing omeprazole!
Mr. Wu is 45 years oldBecause of irregular eating and overeating, I often have stomach pain；Under the recommendation of a friend, Mr. Wu learned about the drug omeprazole, and the friend told Mr. Wu that this drug is the best stomach disease, and the effect is very good, and it is recommended that Mr. Wu buy some to eat, maybe he can cure the stomach disease for many years.
Mr. Wu was very impressed after hearing this, so he went to the community hospital and asked the doctor to prescribe omeprazole for himself.
At the beginning of taking it, Mr. Wu's stomach problem was indeed relieved, but Mr. Wu found thatWhile taking the medicine, my urine became very yellow。Mr. Wu didn't care, thinking that it was a normal reaction to drug metabolism. After the third day of taking the medicine, Mr. Wu got up and washed as usual, as a result, I found that not only my urine was very yellow, but also my eyes and face were yellow. Mr. Wu finally sensed that something was wrong, so he rushed to the hospital for examination.
After the doctor examined Mr. Wu, he sent itAt present, Mr. Wu's jaundice index exceeds several times the normal value, which has reached more than 340, and the aminotransferase index is also several times the normal value, with more than 310This frightened Mr. Wu, so he immediately went through the hospitalization**.
After two days in the hospital, the doctor gave Mr. Wu a detailed examinationCombined with Mr. Wu's experience of taking omeprazole, it was found that Mr. Wu had acute liver injury due to indiscriminate medication。The doctor immediately gave Mr. Wu a liver injury**, and after a week**, Mr. Wu's jaundice and aminotransferase values finally decreased and returned to normal.
At the same time, Mr. Wu was very curious and asked the doctor that he had always had stomach problems, so he took omeprazole, why did he get acute liver damage after taking it, his stomach problems were relieved?
The doctor said that this was caused by Mr. Wu's irrational medication, and not all stomach problems can be treated with omeprazole. In the case of Mr. Wu, stomach problems caused by long-term improper diet can be relieved by taking some ordinary gastrointestinal medicines。Omeprazole is only required if it is confirmed that the patient has digestive disorders such as gastric ulcers, chronic gastritis, etc., after a doctor's diagnosis. However, Mr. Wu did not go through the doctor's diagnosis, but took omeprazole without authorization, and took a lot of doses, so it caused acute liver damage.
In fact, not only Mr. Wu, but also many people are like this, as long as they eat irritating food and their stomach is upset, they will take one or two tablets of omeprazole, thinking that this will relieve stomach discomfort. However, omeprazole is a key monitoring drug, which cannot be eaten indiscriminately, and if you take omeprazole without a doctor's diagnosis, there may be adverse reactions such as acute liver damage. Therefore, everyone must have a basic understanding and cognition of omeprazole.
Omeprazole is an antacid-suppressing drug, which belongs to proton pump inhibitors (PPIS), and is currently one of the first-line prescription drugs for gastric diseases in China. Omeprazole can not only help with diseases such as peptic gastric ulcer, stress gastric ulcer, and upper gastrointestinal bleeding, but also infectious diseases such as gastroesophageal reflux disease and Helicobacter pylori due to excessive gastric acid secretion
However, it is important to note that not all gastric disorders due to excessive acid secretion can be treated with omeprazole**. There are many reasons for excessive gastric acid secretion, for example, eating too many sweet potatoes may also lead to excessive gastric acid secretion, nausea and other conditions, but this situation does not need to be relieved with omeprazole, as long as you take some simple drugs to neutralize gastric acid.
If it is not due to the excessive secretion of gastric acid caused by the disease, there is no need to take omeprazole, otherwise it will only increase the toxicity of the drug and lead to other diseases in the body.
At the same time, when it is necessary to prevent stress ulcers such as cerebral hemorrhage and neurosurgery, omeprazole can also be taken
It can be said that there are many diseases of omeprazole, which are widely used clinically, and the ** of omeprazole is very low, so many doctors will prescribe omeprazole to patients.
Since the clinical application of omeprazole is so wide and the ** is still low, why is omeprazole still listed as a key monitoring drug? This is because,If there is no focused monitoring in the process of taking omeprazole, it is easy to have a variety of other *** such as liver damage, kidney damage, increased risk of cancer and so on
Previously,The well-known medical journal "JASN" has published a study on patients taking proton pump inhibitors such as omeprazole for a long time, and the report pointed out that patients who take proton pump inhibitors for a long time have an increased risk of chronic kidney disease by 28% and uremia by 96% compared with the general populationThis data is terrifying.
There are also drug management departments in the United States and the European Union, which have also published studies on proton pump inhibitors, sayingLong-term use of proton pump inhibitors such as omeprazole may lead to the risk of fractures and hypomagnesemia
And that's not all,Long-term use of proton pump inhibitors such as omeprazole may also increase the risk of stomach cancer
In 2017, the Faculty of Medicine of the University of Hong Kong, China, published a study in which researchers conducted a study on 63 patients who received Helicobacter pylori ** underwent up to 7After 6 years of observation, it was finally found that patients who took proton pump inhibitors such as omeprazole for a long time had a 1-4 times increased risk of stomach cancer than those who did not take it.
Therefore, you must not be like Mr. Wu, use omeprazole indiscriminately, the consequences of indiscriminate use of omeprazole are very serious, everyone must be careful. So, what are the adverse reactions that patients will experience in the process of taking omeprazole?
1) Long-term eating may lead to diarrhea:
Omeprazole belongs to the class of acid-suppressing drugs, so when patients have stomach diseases such as acid reflux, they will take omeprazole, butLong-term use of omeprazole may lead to a decrease in gastric acid concentration, and after the gastric acid concentration is reduced, the virus and bacteria in the stomach may enter the intestines and cause diarrhea
Therefore, doctors recommend that when you take omeprazole, you should not take it for too long, and it is generally 4-8 weeks for a course of treatment.
2) Increase the risk of osteoporosis and fractures in patients:
Omeprazole will affect the body's absorption of calcium, and long-term use of omeprazole may lead to calcium deficiency, osteoporosis and fracture risk。Therefore, during the period of taking the drug, patients should pay attention to calcium supplementation, especially the middle-aged and elderly people, who are prone to calcium deficiency and need to supplement calcium.
3) Affect liver function:
Omeprazole needs the liver to help with metabolism, and if you take omeprazole for a long time, it may affect liver function and lead to impaired liver function
Of course, in addition to the above three cases,Long-term use of omeprazole may also cause adverse reactions such as nausea, constipation, rash, and even kidney damage in some patients. Therefore, doctors recommend that patients should check their blood routine and urine routine once a week while taking omeprazole. If long-term medication is required, attention should be paid to checking renal function and liver function, and omeprazole should be used with caution in patients with liver and kidney insufficiency
Point 1: Do not take omeprazole for a long time
There are many adverse reactions of omeprazole, and if you take omeprazole for a long time, it may lead to increased drug toxicity and burden the body, so it is not recommended for patients to take omeprazole for a long time. Moreover, long-term use of omeprazole will cause a decrease in stomach acid, which is not conducive to food digestion and drug breakdown.
The doctor recommends that you take omeprazole for a course of treatment (4-8 weeks), if there is still no effect after taking a course of treatment, you can consult a doctor and seek help from a doctor.
Point 2: Do not add or subtract the dose by yourself
Many people will increase the dosage without authorization because they feel that the effect is not obvious during the period of taking omeprazole, which is wrongIncreasing the dose can lead to adverse reactions and even damage to other organs and tissues, so don't increase the dose without authorization.
Unauthorized reduction of the dose may lead to insufficient efficacyTherefore, in the process of taking the medicine, the patient should follow the doctor's instructions and take it according to the dosage prescribed by the doctor.
Point 3: Pay attention to drug interactions
Omeprazole is widely used in clinical practice, therefore, omeprazole is often used together with other drugs, but everyone must remember that some drugs cannot be taken with omeprazole.
For example, omeprazole cannot be used in combination with clopidogrel. Clopidogrel is mainly used for antiplatelet fighting, while omeprazole will reduce the antiplatelet effect of clopidogrel and make clopidogrel ineffective, so it is best not to use these two drugs together
There are also prednisone, calcium carbonate, aspirin, statins, etc., which will interact with omeprazole, so it is best not to take them together
Before taking omeprazole, patients must tell the doctor whether they have any diseases and whether they are taking any drugs, so that it can be more convenient for the doctor to diagnose and prescribe drugs.
Omeprazole is a key monitoring drug, so patients should not take it without authorization, but should take it under the guidance of a doctor, and should also pay attention to re-examination and check the physical condition during the taking period.
You must not be like Mr. Wu, indiscriminately use omeprazole, which is very harmful to the body, and there may be serious *** omeprazole should be taken under the guidance of a doctor, and it is not recommended to take it for a long time.
References:1] Xu Guoming et al. "The diagnostic value of the proton pump inhibitor (omeprazole) test in gastroesophageal reflux disease. "Chinese Journal of Digestion 221(2002):4.
2] Wu Haiwu et al. "Efficacy analysis of high-dose omeprazole** in elderly gastric ulcer complicated with bleeding. "Modern Preventive Medicine 395(2012):3.
3] Zhang Xianghong, and Liu Ruixue. "Clinical Study of Low-Dose Omeprazole** Functional Dyspepsia. "Chinese Journal of Practical Internal Medicine 283(2008):211-212.