2-Chloro-5-nitroisonicotinic acid (CAS: 906652-81-1) is a white solid with the chemical formula C6H3ClN2O4 and a molecular weight of 19255。Its melting point is 112-114 °C and its boiling point is 3478 °C with a density of 168 g/cm3。At room temperature, it is insoluble in water, but soluble in a variety of organic solvents such as ethanol and dimethylformamide.
In terms of chemical properties, 2-chloro-5-nitroisonicotinic acid is an important intermediate in organic synthesis, which can undergo a variety of reactions such as electrophilic substitution reaction and nucleophilic substitution reaction. It can be used to synthesize other organic compounds such as drugs, dyes, pesticides, etc.
At present, the synthesis route of 2-chloro-5-nitroisonicotinic acid mainly includes two steps: nitrolation reaction and chlorination reaction. First, under the right conditions, isonicotinic acid is converted to nitroisonicotinic acid, and then chlorination is carried out to obtain the target product. This synthetic route is simple and efficient, and is suitable for industrial production.
The preparation methods of 2-chloro-5-nitroisonicotinic acid mainly include nitrosylation reaction and chlorination reaction. Nitroylation usually uses nitric acid to react with isonicotinic acid to prepare nitroisoniacin, while chlorination is to react nitroisonicotinic acid with a chlorinating agent to prepare the target product. These methods are simple to operate, have high yields, and are suitable for industrial-scale production.
As an important intermediate in organic synthesis, 2-chloro-5-nitroisonicotinic acid has a wide range of applications in drug synthesis, dye synthesis, pesticide synthesis and other fields. It can be used as a precursor for other compounds and involved in the synthesis of complex organic compounds.
Microchannel technology is a synthesis method that has developed rapidly in recent years, and the synthesis reaction can be automated and continuous through microchannel reactors. For the synthesis of 2-chloro-5-nitroisonicotinic acid, microchannel technology has great potential. In the future, with the continuous development of microchannel technology, the synthesis efficiency and yield of 2-chloro-5-nitroisonicotinic acid can be further improved.
In summary, 2-chloro-5-nitroisonicotinic acid, as an important intermediate in organic synthesis, has broad development prospects in synthesis routes, preparation methods, product applications, and continuous development of microchannels. In the future, we can further study its synthesis method to improve the yield and efficiency, and promote the application of this compound in various fields.