The glorious journey of China's leading medicine.
Standing on the starting line of the new year, we can't help but look back on 2023, when the country's top medical workers have worked hand in hand and made remarkable progress with the support of all walks of life. Looking forward to 2024, China will continue to forge ahead and write a beautiful chapter in the history of the development of the world's leading disciplines. In this great journey, many breakthrough scientific research achievements have become the driving force for the new development of China's leading medicine. The following is a detailed description of these achievements, leading us to a glimpse of the glorious journey of China's leading medicine.
1. Transformation of scientific and technological achievements: a new milestone in medicine.
With the continuous development of artificial intelligence technology, it is particularly important to innovate and integrate in the field of medical engineering and promote the technology transfer and achievement transformation of medical institutions. Under the leadership of Gao Xinghua, Qi Ruiqun, Zheng Song and Academician Chen Hongduo, the ** team of the First Affiliated Hospital of China Medical University has successively launched the world's first non-invasive photothermal ** system against cervical human papillomavirus (HPV) infection and the world's first artificial intelligence-assisted pathological analysis system. This is not only a leap in the level of technology, but also a profound expansion of medical research. The team's publication in SCI**, the acquisition of a number of patents and the signing of transformation contracts together constitute a major breakthrough in the transformation of scientific and technological achievements.
2. The international influence of China's leading science.
At the 25th World Congress of Diseases in 2023, Professor Lu Qianqian, Chairman of the 15th Committee of the Chinese Society of Venereal Diseases and Professor of the Second Xiangya Hospital of Central South University, was successfully elected as the executive director of the International Federation of Societies of Diseases (ILDS). This honor is not only a high recognition of Professor Lu Qianjian's personal academic achievements, but also an important recognition of China's leading international status in scientific research. The Board of Directors of ILDS is composed of the world's leading experts in the field of disease and is committed to promoting the exchange and cooperation of the world's best science. This marks that China's first-class science is going to the world and contributing more backbone to the development and prosperity of the world's first-class scientific cause.
3. Glory of Medical Awards: Academician Liao Wanqing's Outstanding Contributions.
On October 11, 2023, Professor Liao Wanqing, academician of the Chinese Academy of Engineering, expert in diseases and mycology, and member of the Faculty of Medicine and Health of the Chinese Academy of Medical Sciences, was awarded the 2023 Wu Jieping Medical Award. This award is a high recognition of Professor Liao Wanqing's outstanding achievements in clinical and scientific research in the field of advanced science. Academician Liao Wanqing's research not only established the first medical fungal preservation and management center in China, but also made a significant breakthrough in the early diagnosis and staging of cryptococcal meningitis. He conducted in-depth research on the new epidemiological characteristics and diagnosis and treatment techniques of important fungal diseases in China and the "Belt and Road" countries, and significantly improved the level of diagnosis and treatment of fungal diseases in China and the "Belt and Road" countries. Academician Liao's achievements are not only a personal commendation, but also the pride of China in the field of medicine.
4. Research progress of systemic lupus erythematosus.
Professor Lu Qianqian's team published two papers in Annalsofrheumaticdiseases**, deciphering the three-dimensional chromosomal structure of T cells in patients with systemic lupus erythematosus (SLE) for the first time, revealing the correlation between the three-dimensional genomic changes of SLE immune cells and disease activity. This study suggests that chromatin interaction plays an important role in the pathogenesis of SLE and identifies the potential impact of genetic variation on three-dimensional genomic alterations in SLE. Using a Bayesian stratified linear mixed model, the team provided reliable estimates of SLE incidence, prevalence, etc., at the global, regional, and national levels, and further provided potential SLE epidemiological data at the global, regional, and national levels by sex and age. This provides important clues for a deeper understanding of the epidemiological characteristics of SLE and guidance**.
5. The first naming of CAOP syndrome: a new height in scientific research.
Professor Yao Zhirong's team from Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine published in Embole CularMedicine**, naming a new disease for the first time in the world - cataract-baldness-oral mucosal disease-psoriasis-like syndrome (CAOP syndrome). This study lasted more than ten years and discovered a new molecular site involved in mitochondrial metabolism, 1 protease (S1P), which regulates mitochondrial metabolism through mitochondrial electron transfer of flavin protein (ETF). For the first time, the team also reported that the membrane-bound transcription factor peptidase (MBTPs1) S1P gene is the causative gene of CAOP syndrome, and elucidated the pathogenic mechanism of MBTPs1 mutation. At the same time, studies have found that vitamin B2 supplementation can improve inflammatory lesions in patients with CAOP syndrome, pointing out the direction for this rare disease.
6. New clues for scar repair.
The team of Professor Gao Xinghua from the First Affiliated Hospital of China Medical University published in STTT**, which studied the basis of scar formation from the perspective of fetal development, and provided new clues for the repair of adult scars**. Through comparative studies, the team found that the interferon regulator IRF7 in the TOLL-like receptor (TLR) signaling pathway activates the transcription of casein S (CTSS), thereby inhibiting fibroblast remodeling of the extracellular matrix. On the contrary, CTSS inhibitors can effectively inhibit the activation of myofibroblasts during hypertrophic scarring, and IRF7 CTSS may be the target of scarring.
7. Study on the mechanism of the occurrence of the first infection of Trichosporum assahi.
The team of Professor Yang Rongya of the Seventh Medical Center of the PLA General Hospital has been focusing on Trichospora asahi (T.Aasahii) systematic ** staining was studied. By building tUsing whole transcriptome sequencing, gene knockdown, real-time quantitative polymerase chain reaction (RT-qPCR), enzyme-linked immunosorbent assay (ELISA), laser confocal microscopy and other techniques in the ASAHII infection model at different time points, the team found macrophage anti-T. at the transcriptional and epitranscriptional levels, respectivelyMultiple regulatory networks and signaling pathways during ASAHII infection. Research confirms tASAHII can achieve slow staining in the host by altering key proteins, phenotypes, and reducing immunogenicity. This result is tThe development of ASAHII system dye drugs provides a new theoretical basis, and the study was published in Military Medical Research.
8. Fill the gap in the diagnosis of atopic dermatitis in China.
Peking University People's Hospital published a report on CMJ, the first nationwide atopic dermatitis (AD) epidemiological survey results were reported for the first time. Through the analysis of the clinical data of 2662 patients in 42 large hospitals across the country, the study summarized the characteristics of China's ** and adolescent AD, and finally formed three concise and clear indicators after a high degree of induction and refinement, and put forward the "Chinese standard" for diagnosis, and the sensitivity is higher than most foreign standards, filling the gap in the field of AD diagnosis in China for a long time.
9. High-quality research on melanoma and psoriasis.
Xijing Hospital of the Air Force Medical University has published a number of high-quality articles on melanoma and psoriasis. Professor Li Chunying's team published a paper revealing the important role and mechanism of SIRT7 in promoting melanoma progression, and SIRT7 is expected to become a new target for melanoma. Wang Gang, Dang Erle and Shao Shuai The team of Professor Wang Gang published in JCI and NatureCommunications for the first time, discovering the IGFBP7HIEC subset for the first time, revealing the mechanism of this subset mediating immune inflammatory disorders in psoriasis lesions, and at the same time determining that CREB1 is a key regulator of CXCR4HI neutrophils, and proposing a new strategy targeting IGFBP7HIEC subset and CXCR4HI neutrophil** psoriasis.
10. Exploring a New Model of Medical Training: The Future of Education.
In the field of undergraduate education, Professor Chen Xiang, an expert from Xiangya Hospital of Central South University, as the first winner, applied for the teaching achievement project "Exploration and Practice of the Unity of Knowledge and Action, the Exploration and Practice of a New Model for the Training of Outstanding Doctors", which won the first prize of the Higher Education Teaching Achievement Award. This award-winning project is the result of repeated research and practice by experts and professors of Xiangya ** Department in the front-line work of medical education, which reflects the achievements and progress of China's ** Department in the reform of clinical practice ability, medical professionalism, curriculum construction and teaching methods.
In conclusion, China's leading medical science has made remarkable achievements in 2023, not only making a number of breakthroughs in the field of scientific research, but also establishing a new image on the international stage. This series of scientific and technological achievements, international influence, medical awards, research progress and educational innovation have laid a solid foundation for the future of China's leading science. Looking forward to the future, China's leading science and medicine will continue to climb the peak of science and contribute more wisdom and strength to the global health cause.
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