MTTP is an important protein, the full name of microsomal triglyceride transfer protein, is a transfer protein found in microsomes of the endoplasmic reticulum. MTTP protein plays an important role in lipid metabolism, it is involved in the transport and synthesis of lipids, and has an important impact on fat absorption in the intestine.
Catalog No. PA1000-9170
First, let's take a look at the basic information about the MTTP protein. The gene for the MTTP protein is located on chromosome 4 of the human genome and encodes a protein containing 894 amino acids. The protein is mainly found in tissues such as liver, small intestine and intestinal cells, with the most abundant expression on the small intestine. MTTP proteins are mainly localized in the endoplasmic reticulum and high-density lipoprotein synthetasomes in the cell.
The main function of MTPP protein is to facilitate the transfer of lipids within cells. In the small intestine of the human body, MTTP proteins bind to fatty acids to form lipid-protein complexes that aid in the absorption process of lipids from the intracellular to the surface of the intestine. This process is essential for the digestion and absorption of fats, especially fat-soluble vitamins.
In addition, MTTP protein is also involved in the regulation of lipid synthesis. MTTP protein, along with other lipid synthases, promotes lipid synthesis and transport by forming complexes in the endoplasmic reticulum, thereby maintaining intracellular lipid homeostasis. This is of great significance for the normal function and metabolism of cells.
The structure of the MTTP protein is also a key factor in its function. The protein contains a signal peptide sequence, an N-terminus and two fat membrane-binding domains, and a C-terminus. The N-terminal and C-terminus are involved in lipid binding and transfer, respectively, while the fat membrane-binding domain contributes to the localization and function of proteins in the endoplasmic reticulum.
Overall, MTTP protein, as a lipid transporter, plays an important role in fat metabolism. By facilitating the transfer and synthesis of lipids, MTTP proteins maintain intracellular lipid homeostasis and also play a key role in the absorption of fats in the gut. Therefore, the study of MTTP protein not only helps to understand the molecular mechanism of lipid metabolism, but also provides new ideas for the prevention and development of related diseases.