ST2 recombinant protein is an important protein that plays an important role in the immune system. Below I will introduce the basic information of the ST2 recombinant protein as well as its functional structure in detail. Catalog No. PA1000-9127
1. Basic Information.
The ST2 recombinant protein, also known as the ST2 protein, is a protein encoded by the ST2 gene. The ST2 gene is located on human chromosome 2 and encodes a protein that contains two subunits, ST2L and ST2S. ST2L is the long subunit of the ST2 recombinant protein, and ST2S is the short subunit. ST2S is formed by selective shearing, which has the same N-terminus as ST2L but a truncated C-terminus. ST2L is the main functional expression form of ST2 recombinant protein.
2. Functions. The ST2 recombinant protein mainly interacts with IL-33 (interleukin 33) and is involved in the regulation of immune responses. IL-33 is a pro-inflammatory cytokine that, when bound to its receptor ST2, activates T cells and other immune cells to promote an inflammatory response. As a receptor for IL-33, ST2 recombinant protein can regulate the IL-33 signaling pathway and inhibit its overactivation, thereby regulating the intensity of immune response.
In addition, ST2 recombinant protein also plays an important role in allergic diseases, autoimmune diseases, infectious diseases, and other aspects. By binding to IL-33, ST2 recombinant protein can affect cytokine secretion, inflammatory mediator production and immune cell activation, which in turn affects the occurrence and development of various diseases.
3. Structure. The structure of the ST2 recombinant protein includes a signal peptide, an extracellular domain, a transmembrane domain, and an endodomain. Among them, the extracellular domain contains three cysteine-rich domains (ig-like domains) that bind to IL-33 to transmit signals. The transmembrane domain can transmit signals into the cell, initiating related signal transduction pathways. Intracellular domains help regulate the activity of signaling pathways.
Overall, the ST2 recombinant protein, as a receptor for IL-33, plays an important role in regulating anti-inflammatory responses, immune cell activation, and inflammatory responses. Its structure and function are complex, and need further research and exploration. It is hoped that in the future, the research on ST2 recombinant protein can provide new ideas and methods for immune system regulation and disease**.