Ethyl 2-nitrobenzoate (CAS: 610-34-4), also known as ethyl 2-nitrobenzoate, is a yellow to orange crystal with a special aromatic odor. Its molecular formula is C9H9NO4 and its molecular weight is 19517 g/mol。The compound has a high melting and boiling point of 107-110 °C and a boiling point of 295 °C. Ethyl 2-nitrobenzoate is a solid insoluble in water at room temperature, but soluble in organic solvents such as ethanol and ether.
The synthesis of ethyl 2-nitrobenzoate can be prepared by nitrolation reaction. A common synthetic route is to react 2-nitrobenzoic acid with ethanol under acidic conditions to produce ethyl 2-nitrobenzoate. This synthesis method is simple and efficient, making it suitable for industrial-scale production.
There are several methods for the preparation of ethyl 2-nitrobenzoate, which can be synthesized by esterification reaction or other methods in addition to nitrolation reaction. However, nitrolation is currently the most widely used preparation method due to its ease of operation and mild reaction conditions.
Ethyl 2-nitrobenzoate has important application value in the field of organic synthesis. It can be used as an intermediate in the synthesis of a variety of compounds, such as drugs, pesticides, dyes, etc. In addition, ethyl 2-nitrobenzoate can also be used as an ingredient in fragrances and flavors, giving products a distinctive smell.
With the continuous development of microchannel technology, continuous production has become one of the development trends of the chemical industry. In the production of ethyl 2-nitrobenzoate, the microchannel reactor can improve the reaction efficiency, reduce waste generation, reduce energy consumption, and have good environmental benefits. Therefore, microchannel continuity has a broad application prospect in the production of ethyl 2-nitrobenzoate.