Introduction: With the development of society and the change of people's lifestyle, cerebral infarction, as a common cerebrovascular disease, has become one of the main killers of human health. In recent years, although the best measures for cerebral infarction have improved, the mortality rate and disability rate are still high. Therefore, it is urgent to find a more effective way. This article will focus on the role and mechanism of edaravone in cerebral infarction, in order to provide new ideas for clinicians and patients.
1. The basic concept and pathophysiological characteristics of cerebral infarction.
Cerebral infarction refers to local cerebral malacia and necrosis caused by ischemia and hypoxia of brain tissue caused by cerebral blood supply disorders. Its main pathophysiological features include:1Inadequate blood supply due to blockage of blood vessels; 2.cerebral cell edema, necrosis; 3.Neurological deficits. The clinical manifestations of cerebral infarction are mainly hemiplegia, aphasia, and consciousness disorder.
2. The pharmacological effects and mechanism of edaravone.
Edaravone acts as a free radical scavenger with strong antioxidant effects. It mainly relieves superoxide anions and hydroxyl radicals in cells and alleviates lipid peroxidation, thereby protecting cells and reducing tissue damage. In addition, edaravone can also improve cellular energy metabolism, enhance the stability of cell membranes, and inhibit inflammation and apoptosis.
3. Application and advantages of edaravone in cerebral infarction**.
In recent years, a number of clinical studies have confirmed that edaravone has significant efficacy in cerebral infarction**. First of all, edaravone can reduce the inflammatory response after cerebral infarction and inhibit apoptosis, thereby reducing brain damage. Secondly, edaravone can improve the energy metabolism of brain cells and promote the recovery of nerve function. Finally, edaravone can also scavenge free radicals, reduce oxidative stress, and prevent the condition from worsening.
Compared with traditional cerebral infarction** methods, such as thrombolysis**, anticoagulation**, etc., edaravone has the following advantages:1Wide range of application, not limited by time window; 2.There are fewer adverse reactions and higher safety; 3.It can be used in combination with a variety of drugs for synergistic effect.
IV. Conclusions. In summary, edaravone, as a new type of free radical scavenger, has shown significant efficacy and good safety profile in cerebral infarction**. However, the current research on edaravone in cerebral infarction** is insufficient, and more large-scale clinical trials are needed to verify its exact efficacy and optimal dose. We believe that in the near future, edaravone will become one of the important options for cerebral infarction**, bringing new hope to patients.