Chinese name: phospholipid-polyethylene glycol-maleimide.
Product name: dspe-peg-mal, dspe-peg-maleimide
Appearance: White liquid, semi-solid or solid, depending on molecular weight.
Solubility: Soluble in some organic solvents.
Molecular weight: 1000, 2000, 3400, 5000, 10000, 20000 (can be customized on demand).
Storage conditions: below 20 frozen, dry, protected from light. Long-term storage inert (argon or nitrogen) protection.
Appearance: viscous liquid or solid powder, depending on the molecular weight.
Uses: Only for scientific research, not for human body.
DSPE-PEG maleimide is a very important compound in drug delivery and biomedical applications, and due to its reactivity with sulfhydryl groups, it is an ideal material for the preparation of drug carriers.
In the reactivity of DSPE-PEG maleimide, the maleimide group plays a very important role. When this compound reacts with a sulfhydryl-containing molecule or cell surface, it can form a stable thioether bond, allowing for efficient binding of the drug to the carrier. This property makes it widely used in the preparation of drug carriers such as liposomes, nanoparticles, and gels.
The synthesis of DSPE-PEG maleimide requires the use of delicate chemical reaction techniques to ensure the quality and purity of the product. Typically, the preparation of this compound requires a multi-step reaction, including the synthesis of DSPE, the introduction of PEG, and the modification of maleimide groups. During the synthesis process, attention needs to be paid to controlling the reaction conditions, such as temperature, pH, and the quality and purity of the reagent.
In addition to its applications in drug delivery, DSPE-PEG maleimide has shown significant value in other areas of the biomedical field. For example, it can be used to prepare biocompatible materials such as tissue engineering scaffolds and biosensors. In addition, using its reactivity, it can also be used to prepare nanoprobes and drug carriers with specific functions, etc.
In conclusion, DSPE-PEG maleimide, as an important reactive phospholipid-PEG derivative, has important application value in drug delivery and biomedical applications. With the in-depth study of its properties and applications, it is believed that it will play a more important role in the future of drug development and biomedicine.