Chinese name: phospholipid-polyethylene glycol-active ester.
Product Name: dspe-peg-nhs
Molecular weight: 1000, 2000, 3400, 5000, 10000, 20000 (can be customized on demand).
Quality Control: 95%+
Storage conditions: -20°C, protect from light and moisture.
Appearance: White solid.
Solubility: Soluble in most organic solvents, such as: DCM, DMF, DMSO, THF, etc. It has good solubility in water.
Uses: Only for scientific research, not for human body.
DSPE-PEG-NHSDSPE-PEG-NHS is a commonly used drug delivery tool, which is composed of DSPE (distearoylphosphatidylethanolamine), PEG (polyethylene glycol), and NHS (active esters). DSPE is an amphiphilic phospholipid that is capable of forming a self-assembling membrane that encapsulates the drug to form a nanoscale drug carrier. PEG is a water-soluble polymer that is able to bind to DSPE to form stable liposomes that protect drugs from damage in the body. NHS is an active ester that binds to drug molecules to immobilize the drug on the surface of liposomes.
DSPE-PEG-NHS has a wide range of applications, and it can be used in a variety of biomedical applications such as drug delivery, gene transfection, vaccination, and so on. In terms of drug delivery, DSPE-PEG-NHS can be used to target drug delivery to diseased tissues, improve the efficacy of drugs, and reduce the quality of drugs In terms of gene transfection, DSPE-PEG-NHS can be used to introduce genes into cells to achieve the purpose of gene **. In terms of vaccination, DSPE-PEG-NHS can be used to deliver vaccine antigens to the immune system to improve the immune efficacy of vaccines.
The synthesis process of DSPE-PEG-NHS is relatively simple, and it can be obtained by the monomer reaction of DSPE, PEG and NHS. The monomers of DSPE and PEG can react in organic solvents to form prepolymers of DSPE-PEG. NHS is then added to the prepolymer and reacts with the carboxyl group in the prepolymer to generate a final mer of DSPE-PEG-NHS. Finally, through post-processing steps such as dialysis and drying, the powder or solution of DSPE-PEG-NHS is obtained.