The basic physical properties of 3-acetylpyridine (N-acetylpyridine) include:
1.Chemical Name: 3-Acetylpyridine.
2.English name: 3-acetylpyridine
3.CAS Number: 350-03-8
4.Molecular Weight: 121137
5.Appearance: Generally colorless to light yellow solid.
6.Odor: May have a specific odor.
7.Melting Point: Usually between about 73-76°C.
8.Boiling Point: about 268°C
9.Solubility: Soluble in many organic solvents such as ethanol, ether and chloroform.
These are some of its basic physical properties.
3-Acetylpyridine has many uses, including but not limited to the following:
1.Organic synthesis: As an important intermediate in organic synthesis, it is often used in the synthesis of other compounds, such as pharmaceuticals, pesticides and dyes.
2.Chemical reagents: widely used in laboratories as solvents and reaction reagents, e.g. as protective groups for amino acids.
3.Pharmaceutical field: used for the synthesis of some pharmaceutical active molecules, can also be used as an important intermediate in drug production.
4.Polymer industry: as a catalyst or additive for polymerization reactions, involved in the synthesis process of polymers.
In general, 3-acetylpyridine has important uses in the fields of organic synthesis, medicine and chemistry.
The upstream products of 3-acetylpyridine mainly include pyridine and acetic anhydride. Pyridine is an aromatic compound containing nitrogen, which is usually extracted or synthesized from coal tar. Acetic anhydride is a compound obtained by catalyzing dehydration with acetic acid or ethanol.
The downstream products of 3-acetylpyridine will involve various organic synthesis products, such as pharmaceuticals, pesticides, dyes, polymers, etc. These products will vary depending on the specific application of 3-acetylpyridine in different fields.
The above is the general situation of the upstream and downstream products of 3-acetylpyridine.
A typical method for the synthesis of 3-acetylpyridine is achieved through the reaction of pyridine and acetic anhydride. Here's a brief description of the synthetic route:
1.Reaction Steps: First, pyridine is heated with acetic anhydride in an appropriate solvent. This reaction usually requires the use of catalysts such as zinc chloride or sulfuric acid.
2.*Product Extraction**: After the reaction is completed, the target product 3-acetylpyridine can be obtained with the appropriate extraction and separation steps.
This is a synthesis route of 3-acetylpyridine, of course, there are other synthesis methods, and the specific reaction conditions and catalysts may vary depending on the synthesis route.
Here are some recommendations regarding the transportation and storage of 3-acetylpyridine:
Transport.
1.*Packaging**: It should be packed in a sealed, moisture-proof container and ensure that the packaging is intact.
2.*Marking**: Must be marked in accordance with the relevant regulations for the transportation of chemicals to ensure safety during transportation.
Storage.
1.*Storage conditions**: It should be stored in a dry, well-ventilated place, away from fire sources and oxidants.
2.*Temperature**: It is recommended to store at room temperature, away from open flames and high temperature environments.
3.*Packaging**: The original sealed packaging should be kept away from moisture and direct sunlight.
It is important to emphasize that specific transport and storage conditions are also determined according to local regulations and chemical characteristics.
When using 3-acetylpyridine, please note the following:
1.*Personal Protection**: Personal protective equipment such as chemical protective glasses, protective gloves and work clothes should be worn when using to avoid contact with ** and eyes.
2.*Ventilation**: Good ventilation conditions should be ensured during operation to avoid inhalation of its vapors.
3.*Avoid swallowing**: Never ingest or swallow 3-acetylpyridine and make sure to keep it away from food and drinking water.
4.*Avoid mixing**: Avoid mixing with strong oxidizing agents or flammable substances, and understand the characteristics and hazards of other chemicals before handling.
5.*Storage**: Keep away from fire and high temperature environment when storing, keep the packaging intact and avoid moisture.
6.*Waste Disposal**: Waste is disposed of in accordance with local regulations and must not be discharged into the environment.
7.*Emergency**: In case of an accident, stop using it immediately and deal with it according to the corresponding first aid measures.
The above are some precautions when using 3-acetylpyridine. The safety data sheet (SDS) of the product should be understood in detail before use, and the relevant safety operating procedures should be strictly followed.