Recently, Professor Wang Yusheng from Shanxi Provincial Cancer Hospital shared his views on the diagnosis and treatment and pathogenesis of esophageal cancer. Professor Wang not only revealed the basic pathogenesis of esophageal cancer, but also shared the latest diagnosis and treatment methods, as well as suggestions for the management of adverse reactions.
Professor Wang Yusheng.
Master's supervisor and postdoctoral supervisor.
Deputy Chief Physician of the Department of Gastroenterology, Shanxi Provincial Cancer Hospital, Doctor of Oncology.
Vice Chairman of the Ethics Committee of Shanxi Provincial Cancer Hospital.
Deputy Director of Shanxi Provincial Gastric Cancer Diagnosis and Treatment Center.
Member of the Expert Committee on Gastric Cancer Quality Control of the National Cancer Quality Control Center.
Member of the Standing Committee of the Oncology Committee of the Chinese Association of Research Hospitals.
Member of the Standing Committee of the Esophageal Cancer Committee of the Beijing Cancer Prevention and Control Society.
Member of the Standing Committee of CACA Integrated Oncology and Nephrology Committee.
Member of the Standing Committee and Deputy Secretary-General of the CACA Esophageal Tumor Integration Committee.
He is a member of CACA Oncology and Hepatology Committee, Oncology MDT Committee, and Oncology Information Management Committee.
He is a member of the Liver Oncology Branch and the Colorectal Disease Branch of the China Medical Promotion Association.
Member of the Digestive Tumor Special Committee of the Beijing Cancer Prevention and Treatment Research Association.
Chairman of the Tumor Heterogeneity and Individualization Committee of Shanxi Anti-Cancer Association.
Vice Chairman of the Tumor Clinical Trial Committee of Shanxi Anti-Cancer Association.
Vice President of the Gastrointestinal Stromal Tumor Committee of Shanxi Geriatrics Society.
He has published 15 SCI articles, presided over 12 provincial and ministerial projects, and 73 PI clinical studies in sub-centers.
Understanding the pathogenesis of esophageal cancer is helpful in the formulation of ** protocols and the monitoring and evaluation of the disease.
Professor Wang Yusheng first emphasized the importance of understanding esophageal cancer for prevention and prevention. Professor Wang pointed out that the pathogenesis of esophageal cancer is diverse, which is the result of environment-gene-gene interaction, and in addition to genetic factors and regional characteristics, gene mutations, RNA interference, DNA damage repair, tumor microenvironment, dietary habits, chronic adverse stimuli, and inflammatory reactions are all involved in Xi the occurrence and development of esophageal cancer. But there is no unification at present.
First, the exact conclusion.
At present, research on the pathogenesis of esophageal cancer focuses on dietary Xi, such as liking to eat hot food and pickled food;There are also Xi effects of daily habits, such as frequent smoking and drinking, stress, irregular meals, etc. There are also problems of regional water and soil, and the accumulation of tumor families, etc., all of which make the incidence of esophageal cancer high.
Understanding the pathogenesis of esophageal cancer can help doctors better understand the progression of the disease, leading to more effective prevention and mitigation programsIn addition, the pathogenesis of esophageal cancer can also help doctors to respond to and prognosis certain regimens, so as to better choose the best regimen for patientsThe pathogenesis of esophageal cancer can also help doctors monitor and evaluate the patient's condition.
A thorough examination and assessment helps to understand the patient's general condition so that an appropriate protocol can be developed.
In terms of diagnosis, Professor Wang Yusheng recommends that the patient's medical history and symptoms should be understood first. In particular, patients with symptoms such as dysphagia, chest pain, nausea, and vomiting should be given great attention. In addition to routine physical examination, imaging tests such as barium x-ray, CT, and MRI are also essential diagnostic tools. These tests can help doctors know the location of the tumor, its size, the depth of invasion, and whether there are lymph node metastases.
When it comes to esophageal cancer, Professor Wang Yusheng said that surgery is the preferred method, and for patients with early esophageal cancer, surgical resection of the tumor can obtain a better survival rate. However, for patients with locally advanced disease, surgery alone has limited effect, so it is necessary to combine chemoradiotherapy, immunology and other comprehensive methods. Professor Wang Yusheng also emphasized the important position of immunity in esophageal cancer. In recent years, clinical trials of immune checkpoint inhibitors** for esophageal cancer have been carried out continuously and have achieved remarkable efficacy. A number of clinical studies have shown that the combination of immunotherapy and chemoradiotherapy has achieved significant efficacy, pathological complete remission has been improved, and the long-term survival benefit is expected to be further improved.
For immune-related adverse reactions, doctors will treat them in a timely manner according to the grade of reaction.
However, immunity** is not without adverse effects. Professor Wang Yusheng pointed out that immune drugs may lead to immune-related adverse reactions, such as rash, pneumonia, and digestive tract adverse reactions. Clinically, it is recommended that patients communicate with doctors in a timely manner, and deal with them accordingly according to the grading of reactions, generally grade 1 immune-related adverse reactions do not need to be stopped immediately, but corresponding symptomatic treatment is required, grade 2 generally needs to be discontinued, and cortisol and other treatments are given, serious adverse reactions such as myocarditis will also be life-threatening, it is recommended to fully recognize the drug before immunization, timely detection and timely treatment. Finally, Professor Wang Yusheng called on the public to remain vigilant against esophageal cancer, and at the same time to look at new methods rationally. He said that while new approaches such as immunization offer new hope, each patient's situation is different, and the regimen should be individualized. Professor Wang expressed the hope that through the continuous accumulation of scientific research and clinical practice, more accurate and effective diagnosis and treatment plans for esophageal cancer patients can be provided.