Chinese name
Phospholipid-polyethylene glycol-glucose.
Glucose-polyethylene glycol-phospholipids.
Product Name: dspe-peg-glucose
glucose-peg-dspe
Properties] white or light yellow viscous body or powder, depending on the molecular weight.
Structural formula].
Purity] more than 95%.
Solubility] DMSO and other organic solvents.
Storage] Protect from light, dry, -20 preservation, avoid frequent dissolution and lyophilization.
Specification] 100mg, 500mg, 1g, 5g, 10g
Product characteristics] Glucose is the basic substance of cell energy, generally the cell surface will express Glut for the intake of glucose, because the tumor loses the ability to control growth, the demand for energy is great, which leads to the overexpression of Glut on the surface of tumor cells to maintain its energy demand, glucose-modified LPS is to use the overexpression of Glut on the surface of tumor cells as a target to achieve precise targeted drug delivery of tumor cells.
The use of glucose as a targeted ligand is a promising modification method, with glucose being widely and low, and glut being highly expressed on tumor cells, which provides the possibility for the application of glucose. Of course, there are still few studies on glucose as a targeted ligand, and most of the studies are carried out in vitro experiments, and more correlation experiments are still needed to test this modification method.
DSPE-PEG-Glucose (phospholipid-polyethylene glycol-glucose) can be used for liposomal LPS, using sugar receptors on the surface of the cell membrane to specifically bind to carbohydrates. Studies have shown that BBB can be mimicked in vitro with glioma cells U87-MG. ResultsOn the surface, modified LPS showed strong drug community and anti-glioma effects after in vitro trans-BBB transport.
Product Range】DSPE-PEG-GLUCOSE Phospholipid-Polyethylene Glycol-Glucose.
DSPE-PEG-galactose phospholipid-polyethylene glycol-galactose.
DSPE-PEG-Mannose phospholipid-polyethylene glycol-mannose.
DSPE-PEG-HA PHOSPHOLIPID-POLYETHYLENE GLYCOL-HYALURONIC ACID.
dspe-peg-heparin phospholipid-polyethylene glycol-heparin.
DSPE-PEG-FA PHOSPHOLIPID-PEG-PEG-FOLIC ACID.
dspe-peg-biotin phospholipid-polyethylene glycol-biotin.
dspe-peg-fitc/cy3/cy5/cy5.5/cy7/cy7.5/icg