The targeted role of glucose in drug delivery involves different strategies and applications, mainly focusing on the following aspects:
Immune cell targeting: Dextran is a naturally occurring, indigestible polysaccharide with immunomodulatory activity that can be specifically recognized by immune cells. This makes it a promising vector for stable, biocompatible, and specific targeted delivery when immunizing**. In particular, it offers an emerging cancer immunity** strategy in targeting tumor-associated macrophages (TAMs). This strategy does not require a high concentration of drugs to directly kill cancer cells, but rather exerts anti-cancer effects by modulating the body's immunity in the tumor microenvironment.
Cancer metabolic regulation: The metabolic properties of cancer cells, particularly aberrant glucose metabolism, provide potential targets for drug delivery. This abnormal metabolism is characterized by increased glucose uptake and lactate production, the so-called Warburg effect. This metabolic state not only supports the survival of cancer cells, but also regulates the immune system through metabolites such as lactic acid, promoting immunosuppression. Therefore, intervening in tumor development by regulating tumor metabolism and related metabolites is a new strategy.
Central nervous system drug delivery: Glucose-mediated drug delivery systems are particularly well-suited to the central nervous system (CNS). Due to the high selectivity of the blood-brain barrier (BBB), most drugs have difficulty entering the brain. Glucose-mediated drug delivery bypasses the blood-brain barrier by linking the drug to a glycan group and utilizing endogenous glucose transporters. Drugs of this strategy show improved cell permeability, enhanced biodistribution, stability, and low toxicity. For example, glycosylation of ibuprofen and different opioids can improve their central effects.
In general, the targeted effect of glucose in the drug delivery system not only provides a new pathway, but also provides new possibilities for the efficient delivery of drugs and the improvement of the best effect.
Chinese name] amino-polyethylene glycol-glucose.
Glucose-polyethylene glycol-amino group.
Product Name: NH2-PEG-glucose
glucose-peg-nh2
Structural formula].
Product characteristics] NH2-PEG-glucose (amino-polyethylene glycol-glucose), which is formed by combining polyethylene glycol and glucose, and introduces amino functional groups on the polyethylene glycol molecule.
NH2 can be used to modify proteins, peptides, and other materials by carboxyl groups (-COOH) or other amine-reactive chemical groups. PEGylated amino groups easily react with succinimidyl esters (NHS), activated carboxyl groups (-COOH), aldehyde groups, and many other functional groups.
PEG can increase water solubility, degradability, increase drug stability, control drug release, and improve the half-life of drugs in the blood, which can improve the efficacy and safety of drugs.
In terms of cell targeting, the specific binding of glucose to glucose transporters on target cells can increase the intracellular uptake and bioavailability of drugs. Therefore, glucose derivatives have a wide range of application prospects in tumors** and other aspects.
Product Family] NH2-PEG-DSPE Amino-Polyethylene Glycol-Phospholipid.
NH2-PEG-NH2 amino-polyethylene glycol-amino.
NH2-PEG-DBCO amino-polyethylene glycol-diphenylcyclooctyne.
NH2-PEG-COOH amino-polyethylene glycol-carboxyl.
NH2-PEG-MAL amino-polyethylene glycol-maleimide.
MPEG-NH2 methoxy polyethylene glycol amino.
4arm 8arm-peg-NH2 multi-arm polyethylene glycol amino.
NH2-PEG-glucose amino-polyethylene glycol-glucose.
NH2-PEG-galactose amino-polyethylene glycol-galactose.
dspe-peg-glucose phospholipid-polyethylene glycol-glucose.
DSPE-PEG-Mannose phospholipid-polyethylene glycol-mannose.
DSPE-PEG-HA Phospholipid-PEG-HYALURONIC ACID.
dspe-peg-heparin phospholipid-polyethylene glycol-heparin.