IT Home reported on December 19 that DNA is the cornerstone of life, consisting of four letters or nucleotides: A, T, G, and C. Scientists for a long time,They all hope to master the "DNA building block" technology to create effective artificial DNA.
The research team at the UC San Diego's School of Pharmacy and Pharmaceutical Sciences at Skags has taken another step toward this goalBy creating DNA with new nucleotides, and by generating specified proteins, new drugs can be developed for certain diseases.
Dr. Dong Wang, senior author of the study, explained that this opens new doors to the creation of artificial DNA, showing multiple potentially important uses.
The project was developed by Wang, Steven ADr. Benner leads with Dr. Dmitry Lyumkis. Together, the three authors show that not only can you create artificial DNA, but artificial nucleotides can also help create customized proteins that we can use to target specific diseases that are difficult to fight.
Note: The four nucleotides that make up DNA are adenine (A), thymine (T), guanine (G), and cytosine (C).
In the DNA molecule, nucleotides form base pairs with a unique molecular geometry called Watson and Crick geometry (Watson-Crick), named after the scientist who discovered the double helix structure of DNA in 1953.
The new study used an artificial extended genetic information system (AEGIS)., containing two new base pairs. By isolating RNA polymerases from bacteria, scientists tested their interactions with synthetic base pairs, resulting in a Watson and Crick geometry similar to natural base pairs.
The results of the study showed that the enzymes that transcribed the DNA were unable to distinguish between these synthetic base pairs and those found in nature.
IT Home attaches ** Reference Address: OH, J, shan, z., hoshika, s. et al. a unified watson-crick geometry drives transcription of six-letter expanded dna alphabets by e. coli rna polymerase. nat commun 14, 8219 (2023).