In the previous popular science, we often said that tumor targeting** needs to be accurately targeted, so genetic testing is very important. If you are interested, you can take a look at my popular science (about the importance of genetic testing).
Here, we mainly answer your questions: how to do genetic testing?Do you want to have your blood drawn?Should the tumor be re-biopsied?
First of all, I would like to share with you a concept:Germline mutationswithMutations in the system
Germline mutations, as the name suggests, are brought out of the embryo, that is, they can be inherited, they are obtained from the parents, and they are also passed on to the next generation. In other words, your immediate family members (parents, siblings, children) may have the mutation.
Systemic mutations, on the contrary, are acquired, and this gene is a mutation that is discovered until later mutations, then your immediate family members are safe.
Now that we understand the above concepts, let's talk about how to do itThere are generally two kinds: blood test and tumor test
If the blood is tested and there is a genetic mutation, then you will be told with certainty that the mutation is germline (heritable).
If the tumor is detected and there is a gene mutation, we can only say that it may be a germline + system mutation, so which one is it, and blood must be drawn for further verification: if there is a gene in the blood, then it is the germline;If there is no blood in it, then it is a system mutation.
From the above, it can be seen that the detection of tumors can detect a wider range of mutations, and the germ line + system can be wiped outIf the blood is drawn first, it can only cover the germline, and whether there is a systemic mutation cannot be detected.
Moving on to the next question, tumor, what is tumor?It can roughly include 2 parts: 1) pathological section (pathological section after surgery, generally required within 5 years, and within 2-3 years of the current year is better);2) Fresh tumors, during surgery, or puncture pathologies.
I hope my popular science can help you!