This article is from "Nankai Sun Pharmacist", which is used for medical science popularization for reference. The main ingredients are Astragalus, peach kernel, rhubarb, Curcuma, Prunella vulgaris, Motherwort, Tu Fu Ling, Coix seed, cinnamon, North bean root, Platycodon, Sichuan hyssop and other 12 flavors of traditional Chinese medicine, among which Astragalus membranaceus and peach kernel are the Jun medicine, Astragalus membranaceus invigorates qi and solidifies the surface, dissipates blood stasis, diuresis and swelling, peach kernel invigorates blood and dispels stasis, especially good at removing bladder stasis. Rhubarb, Curcuma, Prunella vulgaris, Motherwort, Poria cocos are the subordinate medicines, Rhubarb invigorates blood and dispels stasis, Curcuma performs qi and invigorates blood, Prunella vulgaris clears liver fire, disperses stasis, motherwort invigorates blood and water, and Poria cocos clears dampness and heat. Raw barley, cinnamon, northern bean root, bellflower as adjuvants, cinnamon is warm, can make up for the shortcomings of rhubarb, prunella, poria cocos, and northern bean root too bitter cold, in order to prevent the bitter cold from damaging the yang and stomach, and can assist Jun medicine and medicine to remove stasis, the north bean root is bitter cold, which helps Poria cocos to relieve the heat of the bladder. Oxknee is a medicine, which can invigorate blood and lead medicine downward. It is suitable for qi deficiency and blood stasis, dampness and heat blockade syndrome, and the symptoms are difficulty urinating, frequent urgency to urinate, or lower abdomen distension or pain, pale purple tongue or petechiae, thin yellow and greasy, and thin pulse.
Modern pharmacological studies have found that Astragalus capsule has 1 receptor antagonistic effect, which can relax the smooth muscle of the prostate and bladder, reduce the bladder outlet resistance, reduce the residual urine volume, and effectively improve the lower urinary tract symptoms such as dysuria, urinary frequency, urgency, and urinary tract irritation caused by prostatic hyperplasia. In addition, Astragalus capsule also has the inhibition of 5-reductase, which can inhibit the activity of 5-reductase in prostate tissue, reduce the content of dihydrotestosterone in the blood and prostate, reduce the volume of the prostate, effectively improve the symptoms of acute urinary retention caused by prostatic hyperplasia, and increase urine flow. Finally, Astragalus capsule can also inhibit the expression of prostate smooth muscle contractile factor, increase the content of prostate smooth muscle relaxation factor, thereby reducing prostate smooth muscle tone, relaxing prostate smooth muscle, improving the clinical symptoms of prostatic hyperplasia, reducing prostatic fibroblast proliferation, and inhibiting prostate tissue hyperplasia.
Human clinical studies have confirmed that Astragalus capsule can reduce the volume of the prostate, improve the maximum urinary flow rate and average urinary flow rate, and improve the clinical symptoms of patients with prostatic hyperplasia, such as laborious urination, unobstructed urination, incomplete urination, nocturia, urgency, frequent urination, etc., and improve the quality of life. For patients with prostatic hyperplasia with weakened or even loss of detrusor urinary muscle function, especially patients with no obvious prostate volume increase, Astragalus capsule combined with tamsulosin can be used to exert a synergistic effect, further improve lower urinary tract symptoms, and enhance the best effect.
In terms of usage and dosage, 4 capsules each time, 3 times a day, it is recommended that 42 days is a course of treatment, which can effectively improve the clinical symptoms of patients with prostatic hyperplasia, and can extend the time of taking the drug according to the condition. In terms of safety, a small number of patients had symptoms such as nausea, acid reflux, abdominal pain, diarrhea, constipation, abdominal distention, stomach discomfort, stomach fullness, chest tightness and discomfort, palpitations, and painful urination, and a small number of patients had mild abnormalities in liver and kidney function after medication, and individual patients had elevated urine red blood cells, urine protein, and urine glucose after medication, and red blood cells in stool examination.