Vitamin B12, also known as cobalamin, belongs to group B water-soluble vitamins, is the last vitamin to be discovered, and the only vitamin containing metal elements, the human body itself can not synthesize, need to be supplied through food, vitamin B12 is rich in animal offal, lean meat, fish, eggs, dairy products and other foods, need to be combined with internal factors from gastric mucosal epithelial cells to be absorbed by the human body, vitamin B12 is a trace element, the human body needs it very little, can eat normally, generally will not be lacking, People with gastrointestinal diseases are prone to vitamin B12 deficiency due to insufficient secretion of intrinsic factors.
Vitamin B12 participates in the metabolism of carbohydrates, proteins and fats in the form of coenzymes in the human body, promotes protein synthesis, improves the utilization of folic acid, improves brain metabolism and brain function, enhances memory, calms and calms the nerves, participates in the synthesis of neurotransmitters, maintains the normal function of the central nervous system, promotes the maturation and ** of red blood cells, maintains the normal hematopoietic function of the body, participates in the methylation and metabolism process of homocysteine, reduces plasma homocysteine levels, and is suitable for vitamin B12 deficiency. Such as pernicious anemia, hyperhomogalusinemia, peripheral neuropathy, etc.
Due to the reduction of vitamin B12 intake, complete vegetarians can lead to vitamin B12 deficiency, congenital intrinsic factor deficiency, leading to vitamin B12 malabsorption, and can also lead to vitamin B12 deficiency, thereby inducing pernicious anemia, hyperhomocysteinemia and other diseases, and need to supplement vitamin B12. In addition, for patients with type 2 diabetes who have been taking metformin for a long time, changes in small intestinal peristalsis can stimulate the overgrowth of intestinal flora, competitively inhibit vitamin B12 absorption, and easily lead to vitamin B12 deficiency, requiring long-term vitamin B12 supplementation.
For patients with reduced vitamin B12 intake or malabsorption, it is recommended to take 1000 g of vitamin B12 daily for the first month, and the maintenance dose is 125-500 g per day, for patients with pernicious anemia, it is recommended to take 500 g of vitamin B12 per day until the blood picture returns to normal, it is recommended that patients with type 2 diabetes who take metformin for a long time should appropriately increase the intake of meat, fish, eggs, milk and other foods, and test the vitamin B12 level once a year, and if there is a deficiency, vitamin B12 should be appropriately supplemented, For patients with hyperhomocysteinemia, it is recommended to take 400 ug of vitamin B12 daily, and if it cannot be removed**, lifelong medication is required.
Vitamin B12 is a water-soluble vitamin, water-soluble is strong, it is difficult to store it in the water-based environment of the human body for a long time, if you take vitamin B12 on an empty stomach or before a meal, the drug is quickly absorbed after reaching the intestines, the blood concentration rises rapidly, it is too late to be fully utilized, it will be excreted through the kidneys with urine, if you take vitamin B12 after a meal, there is food, it can delay the absorption of vitamin B12 in the intestine, the drug can be used more fully, the effect is better, therefore, It is recommended to take vitamin B12 30 minutes - 1 hour after a meal. It should be noted that vitamin C can destroy vitamin B12, and when used or long-term intake of vitamin C in large quantities, it can reduce the blood concentration of vitamin B12, therefore, vitamin B12 should be avoided in combination with vitamin C, and when taking vitamin B12, a large intake of fresh vegetables, fruits and other foods rich in vitamin C should also be avoided.
Regular consumption of vitamin B12 may cause eczema, urticaria, asthma attacks, and even anaphylactic shock, and can induce facial edema, nerve excitement, palpitations, chills, and can also promote the growth of malignant tumors. In addition, vitamin B12 can promote nucleic acid degradation, increase blood uric acid levels, lead to hyperuricemia, and even induce gout, **severe megaloblastic anemia, in the first 48 hours of the beginning**, may cause severe hypokalemia, long-term high doses can cause thrombocythemia, increase the risk of sudden death. It has been clinically reported that inappropriate use of vitamin B12 for more than 3 months may lead to irreversible nerve damage, so it is recommended that the course of vitamin B12 should not exceed 3 months.
Gamma oryzanol is a mixture of oils, mainly extracted from rice bran oil and germ oil, the main components are ferulic acid esters and phytosterols, which have the effect of regulating autonomic nerve dysfunction and endocrine balance disorders, and are suitable for neurosis, menopausal syndrome and premenstrual syndrome**, which helps to improve the patient's nervous and anxious mood, calm and help sleep. In addition, gamma oryzanol has a certain regulatory effect on neurasthenia and insomnia, and is suitable for the elderly to assist mild sleep maintenance disorders**, reduce the number of early awakenings, but it is ineffective for moderate and severe insomnia.
Vitamin B12 can maintain nervous system stability, eliminate irritability, concentration, for patients with mood disorders such as irritability, anxiety, depression, etc., the use of vitamin B12 combined with gamma oryzanol can help improve symptoms and improve sleep quality. For patients with neurasthenia, the use of gamma oryzanol in combination with vitamin B12 can help improve clinical symptoms and improve quality of life. Gamma oryzanol can improve autonomic symptoms such as nausea, vomiting, phonophobia, and photophobia caused by migraine by regulating autonomic nerve disorders, vitamin B12 can improve the metabolism of nerve myelin sheaths and maintain the normal function of the nervous system, and gamma oryzanol combined with vitamin B12 helps relieve migraine and other accompanying symptoms, and is suitable for migraine adjunct**.