TNFRSF17, also known as B cell maturation antigen (BCMA), is a cell membrane receptor that plays an important role in the human immune system. The maturation and activity of the TNFRSF17 protein requires binding to two cytokines, TNFSF13B (also known as BLYS or B cell-activating factor) and TNFSF13B (also known as April or A Proliferation-Inducing Ligand). TNFRSF17 is mainly expressed on mature B lymphocytes and plasma cells, and its signaling pathway plays an important role in the proliferation, survival and differentiation of B lymphocytes. Catalog No. PA1000-7605
In order to better study and utilize the biological function of TNFRSF17, scientists have begun to develop and produce the recombinant protein of TNFRSF17. The recombinant protein of TNFRSF17 is a recombinant engineering technique that transfers the human TNFRSF17 DNA sequence into the appropriate expression host cells to produce a large number of TNFRSF17 protein.
The biological functions of the recombinant protein of TNFRSF17 mainly include the following aspects:
1.B lymphocyte activation and proliferation: TNFSF13b and TNFSF13b, when combined with TNFRSF17, can activate B lymphocytes and promote their proliferation and differentiation. The TNFRSF17 recombinant protein can mimic this process, promote the proliferation and activation of B lymphocytes, and contribute to the formation and enhancement of immune responses.
2.Plasma cell differentiation and antibody production: The TNFRSF17 signaling pathway also promotes the differentiation of B lymphocytes into plasma cells, thereby increasing antibody production. The recombinant protein of TNFRSF17 has been confirmed to promote the formation of plasma cells in in vitro culture, providing a new research direction for vaccines and immunization**.
3.Immune cell activation and inflammation regulation: TNFRSF17 recombinant protein also plays an important role in regulating immune cell activation and inflammatory response. Studies have shown that the TNFRSF17 signaling pathway can regulate the production of inflammatory factors and the activation status of immune cells, which has a potential application prospect for inflammatory diseases.
In conclusion, the recombinant protein of TNFRSF17 has shown great potential in the study of biological functions, which can not only help us better understand the regulatory mechanism of the immune system, but also provide new strategies and means for immune** and vaccine development. In the future, with the in-depth research and continuous progress of TNFRSF17 signaling pathway and technology, it is believed that TNFRSF17 recombinant protein will play a more important role in the field of immunology.
In conclusion, the comprehensive analysis of the biological function of TNFRSF17 recombinant protein will provide new ideas and possibilities for research and clinical application in the field of immunology. Let us focus on and support this important research area and jointly promote the development and progress of immunology.