Introduction.
SIRT7 is the only member of the well-known histone deacetylase family located in the nucleus. It is abundant in the nucleus, and a wide range of deacetylated targets have a wide range of effects, implicating DNA replication, transcriptional regulation, and cellular relevance. As a result, researchers are increasingly interested in the structure and function of the protein and how it can be regulated. Catalog No. PA1000-8067
Preparation and structure of SIRT7 recombinant protein.
With recombinant technology, researchers can prepare SIRT7 recombinant proteins in large quantities for further biological studies. The SIRT7 protein contains a conserved NAD+ binding domain and a precise proteolytic acetylase-threoning domain. Studies have shown that both domains play a crucial role in the function of SIRT7. In addition, the researchers also resolved the high-resolution structure of the SIRT7 protein through crystallography and other techniques, revealing the mechanism of its binding to the substrate.
The role of SIRT7 in transcriptional regulation.
As a deacetylase, SIRT7 plays an important role in transcriptional regulation. It has been found that SIRT7 can interact with transcription factors, RNA polymerases, and other transcriptional regulators to regulate gene expression through deacetylation. In addition, overexpression or deletion of SIRT7 can lead to abnormal expression of genes, which can affect the normal function of cells.
The role of SIRT7 in DNA replication.
In addition to its role in transcriptional regulation, SIRT7 is also involved in the regulatory process of DNA replication. Studies have shown that SIRT7 can deacetylate protein complexes and affect the activity of enzymes such as DNA replication enzymes, thereby affecting the DNA synthesis and replication process. This discovery reveals the important role of SIRT7 in the cell** and proliferation process.
The role of SIRT7 in cells.
SIRT7 is also closely related to the process of apoptosis. It has been found that SIRT7 can regulate key proteins in related signaling pathways through deacetylation, which can affect the life and death decisions of cells. Therefore, the role of SIRT7 in cellular processes cannot be ignored.
Conclusion. SIRT7 recombinant protein plays an important role in biological research. Through a comprehensive analysis of its structure and function, we can better understand the mechanism of action of SIRT7 in the nucleus, and provide new ideas and methods for related diseases.