Product name: C12 C16 C18-PEG-C12 C16 C18
Chinese name: polyethylene glycol dilaurel palm stearate amide ether, alcohol dilaurel palm stearate amide ether-polyethylene glycol-alcohol dilaurel palm stearate amide ether.
Molecular weight: 1000, 2000, 3400, 5000, 10000, 20000 (can be customized on demand).
End group substitution rate: 95%.
Structural Formula:
Purity (PEG): more than 95%.
Substitution rate (C12, C16, C18): more than 95%.
Dispersion coefficient (PDI): less than or equal to 105
Properties: viscous liquid or solid powder, depending on the molecular weight.
Storage conditions: Protect from light, dry, -20 storage.
Precautions: Be sure to dry when taking and avoid frequent dissolution and freeze-drying.
Tips: This reagent is only used for scientific research or industrial applications, and is not medicinal or edible.
1. Introduction to C12 C16 C18-PEG-C12 C16 C18.
C12 C16 C18-PEG-C12 C16 C18 is an amphiphilic phospholipid polyethylene glycol derivative, which is commonly used in the preparation of liposomal drugs. This compound consists of a hydrophobic hydrocarbon group (C12 C16 C18) and a hydrophilic polyethylene glycol (PEG) chain and is amphiphilic. Due to its unique structure, C12 C16 C18-PEG-C12 C16 C18 can self-assemble to form liposomes for use in areas such as drug delivery and genetics.
2. Synthesis and properties of C12 C16 C18-PEG-C12 C16 C18.
Synthesis: Polyethylene glycol is usually reacted with the corresponding long-chain fatty acids by esterification reaction to generate corresponding amphiphilic phospholipid polyethylene glycol derivatives. The reaction conditions are mild, the yield is high, and the purity is good.
Properties: Due to their amphiphilic structure, such compounds have good solubility and stability in water and can form stable liposomes. In addition, the physical properties and biological behavior of liposomes can be regulated by changing the length and composition of PEGs and hydrocarbon groups.
3. Application fields and prospects.
Drug delivery: The use of liposomes as drug carriers can significantly improve the solubility and stability of drugs, reduce toxicity, and reduce toxicity C12 C16 C18-PEG-C12 C16 C18 Liposomes have broad application prospects as drug carriers in anti-tumor, anti-virus and other fields.
Gene**: Gene drugs are delivered into cells through liposomes, which can realize the introduction and expression of genes. The use of C12 C16 C18-PEG-C12 C16 C18 liposomes as gene delivery vectors can overcome the efficiency and safety problems of genes.
This article was compiled and edited by Xi'an Kaixin Biotechnology***kls.