Dry granulation technology is a new type of granulation method, which has the advantages of simple process, energy saving and environmental protection. In pharmaceutical production, the application of dry granulation technology has been gradually promoted. This article will provide an overview of the application of dry granulation technology in pharmaceutical production.
1. The principle of dry granulation technology
Dry granulation technology is a method of directly pressing powdered materials into granules under high pressure. This technology eliminates the need for binders, which can lead to drug degradation and deterioration due to moisture introduction in wet granulation. Dry granulation technology has the characteristics of low energy consumption, low pollution and high product quality.
2. Application advantages of dry granulation technology in drug production
1.Improve the quality of medicines
Dry granulation technology can prepare particles with uniform particle size, suitable density and good solubility, and improve the dissolution rate and bioavailability of drugs. In addition, dry granulation technology can effectively avoid the degradation and deterioration of drugs that may be caused by water introduction in wet granulation.
2.Energy saving and environmental protection
Dry granulation technology eliminates the need for binders and solvents, reducing energy consumption and environmental pollution. Compared with wet granulation, dry granulation technology has higher energy efficiency and environmental performance.
3.The process is simple
The process flow of dry granulation technology is simple and easy to operate. In the process of pharmaceutical production, the production cycle can be shortened and the production cost can be reduced. At the same time, dry granulation technology has lower requirements for equipment, which reduces equipment investment and maintenance costs.
4.Wide range of applications
Dry granulation technology is suitable for the preparation of a wide range of pharmaceutical products, including oral solid dosage forms, granules, and direct tableting. For heat-sensitive, hygroscopic, and oxidizing drugs, dry granulation technology has unique advantages.
3. Application examples of dry granulation technology in drug production
1.Antibiotics
Antibiotics have strong antibacterial effects, but they are easily degraded by environmental factors such as humidity, temperature, and oxidation. The preparation of antibiotic granules by dry granulation technology can effectively protect the activity of the drug and improve the product quality.
2.Antineoplastic drugs
Anti-tumor drugs have high activity and toxicity, and have high requirements for granulation process. Dry granulation technology can prepare anti-tumor drug particles with uniform particle size and good stability, reducing the risk of drug toxicity to production equipment and operators.
3.Traditional Chinese medicine preparations
The composition of traditional Chinese medicine preparations is complex, containing a variety of active ingredients and impurities. The preparation of traditional Chinese medicine granules by dry granulation technology can improve the stability and solubility of the preparation and reduce the content of impurities.