Lysophosphatidic acid receptor 1 (LPAR1) is an important G protein-coupled receptor in the human body, which plays an important role in physiological processes such as cell signaling, cell proliferation, cell migration, and cell adhesion. During these physiological processes, LPAR1 can bind to lysosomal acid-deoxyneuronal activation precursors (LPAs) produced by lysosomes and mediate cell signaling. The activation of LPAR1 leads to an increase in intracellular calcium concentration, which in turn activates a variety of signaling pathways and affects cell function. Catalog No. PA1000-9397
The LPAR1 gene is located on human chromosome 9q313, contains 3509 base pairs, encoded as a protein containing 363 amino acids. The structure of LPAR1 includes an N-terminal extracellular domain, seven transmembrane domains, and a C-terminal intracellular domain. The extracellular domain contains a binding position to LPA, and by binding to LPA, LPA1 can initiate downstream signaling pathways, such as RHO, MAPK, and PI3K. The intracellular domain, on the other hand, is coupled to G proteins, activating different signaling molecules.
LPAR1 is widely distributed in the human body, especially in the central nervous system and kidney. In the central nervous system, LPAR1 expression is closely related to neuronal development and function. In the cardiac system, the activation of LPAR1 can cause cardiomyocyte hypertrophy and proliferation, which is involved in the development of myocardial fibrosis. In the lungs, activation of LPAR1 can also lead to smooth muscle contraction and the development of lung disease. In addition, LPAR1 also plays an important role in the liver and kidney, and is involved in physiological processes such as lipid metabolism and cell proliferation.
The aberrant expression of LPAR1 is associated with the occurrence and development of many diseases, such as cardiovascular diseases, neurological diseases, etc. In cancer, overexpression of LPAR1 is associated with the occurrence and metastasis. Therefore, it is of great significance to study the function and regulatory mechanism of LPAR1 to reveal the pathogenesis of related diseases, as well as the diagnosis and regulation of diseases.
In conclusion, LPAR1, as an important G protein-coupled receptor, plays a crucial role in cell signaling and physiological processes. Understanding the basic information and functional structure of LPAR1 is of great significance for in-depth study of its role in disease initiation and progression, and is helpful to provide new targets and strategies for related diseases.