SLC30A1 is a zinc ion transporter, also known as zinc ion transporter 1. It is a transmembrane protein that plays an important role in cell membranes and is involved in a variety of cellular physiological processes, such as cell proliferation, differentiation, and immune response, by regulating the balance of zinc ions inside and outside cells.
Catalog No. PA1000-9407
The protein encoded by the SLC30A1 gene contains a total of 374 amino acids with a molecular weight of about 418 kda。Structurally, SLC30A1 is composed of six transmembrane regions, an extracellular N-terminus, an intracellular C-terminus, and multiple phosphatidylinositol glycosylation sites. Intracellularly, SLC30A1 promotes the transport of zinc from the cytosol to the outside of the cell by binding to zinc ions, thereby maintaining the balance of zinc ions in the cell and affecting the life cycle and function of the cell.
SLC30A1 plays an important role in the cellular immune response. Studies have shown that SLC30A1 can regulate the concentration of zinc ions in antigen-presenting cells, thereby affecting the proliferation and immune response of T cells. In addition, SLC30A1 is also involved in the regulation of the activation of intracellular ROS (reactive oxygen species) and NF-B signaling pathways, which in turn affects the activation and function of immune cells.
In addition to being involved in the immune response, SLC30A1 also plays a key role in cell growth, differentiation, and apoptosis. Studies have shown that SLC30A1 can regulate the concentration of cytosolic zinc ions, which in turn affects cell growth and proliferation. In some cell lines, overexpression of SLC30A1 can lead to inhibition of cell growth and proliferation.
Overall, SLC30A1 is an important zinc ion transporter that plays an important regulatory role in cellular physiological processes. By regulating the balance of zinc ions inside and outside cells, SLC30A1 is involved in key physiological processes such as immune response, growth, and differentiation of cells. Therefore, the study of SLC30A1 is helpful to better understand the regulatory mechanism of intracellular copper-zinc balance, and provides new ideas and targets for the prevention and development of related diseases.