SGPP1 recombinant protein is a protein with important biological functions, which plays an important regulatory role in cells. In this article, the basic information, function and structure of SGPP1 recombinant protein will be introduced in detail.
1.Basic Information.
SGPP1 recombinant protein is a protein encoding the human gene SGPP1, which is called Sphingosine-1-phosphate phosphatase 1. This gene is located on human chromosome 10 q21Zone 3, is a phosphatase. The SGPP1 protein contains 305 amino acid residues and has a molecular weight of about 34 kDa. Catalog No. PA1000-9350
2.Function.
The SGPP1 protein mainly plays a role in the cytoplasmic membrane, and its main function is to catalyze the hydrolysis of sphingosine-1-phosphate (S1P) to sphingosine. S1P is an important cell signaling molecule that is involved in the regulation of a variety of biological processes, such as cell proliferation and migration. SGPP1 protein regulates its concentration by degrading S1P, thereby affecting a variety of cellular physiological activities. Studies have shown that SGPP1 plays an important role in the occurrence and development of inflammation, autoimmune diseases, and other diseases.
3.Structure.
The structure of SGPP1 protein is closely related to its function. Its molecular structure consists primarily of a phosphatase domain containing a series of highly conserved amino acid residues, including sites for specific binding to substrate S1P. Through these conserved amino acid residues, SGPP1 protein can effectively catalyze the hydrolysis of S1P and realize the regulation of S1P concentration.
In addition, the SGPP1 protein also contains an extracellular domain containing a conserved sequence at its C-terminus, which may be involved in the interaction of SGPP1 with other proteins. Through these interactions, SGPP1 protein may be involved in the regulation of a variety of cell signaling pathways and affect cell function.
Overall, the SGPP1 recombinant protein plays an important role in cell signaling and cell physiology. Its regulation of S1P concentration, the regulation of various cellular processes, and its interaction with other proteins provide an important reference for us to understand the intracellular signaling pathways and the occurrence and development of diseases. Hopefully, this article will help readers better understand and recognize the SGPP1 protein.