Prostaglandin F2 Receptor Negative Regulator (PTGFRN) is a protein whose main function is to negatively regulate the expression and signaling of prostaglandin F2 receptor (FP receptor). PTGFRN can be reconstituted and used to study the biological processes of prostaglandin F2 regulation and related diseases. The basic information, functions, and structure of PTGFRN are described in detail below.
1. Basic Information.
1.Genes: The PTGFRN gene is located on human chromosome 9 and encodes a protein with a length of about 2000 base pairs.
2.Sequence: The PTGFRN protein is composed of about 500 amino acids and has a molecular weight of about 55 kDa.
3.Distribution: PTGFRN is mainly expressed in tissues such as the nervous system, heart, prostate, and kidney.
Catalog No. PA1000-9337
2. Functions. 1.Negatively regulates FP receptor expression: PTGFRN reduces the expression of FP receptors on the cell membrane by regulating the transcription and translation levels of FP receptor genes, thereby attenuating prostaglandin F2 signaling mediated by FP receptors.
2.Inhibition of prostaglandin F2-mediated biological effects: PTGFRN can interfere with the binding of prostaglandin F2 to its receptors, thereby attenuating the biological effects of prostaglandin F2-regulated inflammatory response, cell proliferation, and blood pressure.
3. Structure. 1.Domains: PTGFRN contains an N-terminal signal peptide, 7 transmembrane domains, and a C-terminal intracellular domain. Among them, the transmembrane domain is a key domain in which PTGFRN interacts with FP receptors.
2.Three-dimensional structure: The three-dimensional structure of PTGFRN presents a unique folding pattern with special functions, which provides basic support for the function of PTGFRN.
3.Effect with FP receptors: PTGFRN inhibits the activity of FP receptors by binding to FP receptors to form complexes, thereby affecting F2-mediated signaling pathways.
In conclusion, PTGFRN is an important negatively regulatory protein that affects the biological effects of prostaglandin F2 by regulating the expression and signaling of FP receptors. The in-depth study of PTGFRN is helpful to reveal the regulatory mechanism of prostaglandin F2 signaling pathway, and provide new ideas for related diseases.