Article 2009Brain Science**
March 4, 2023day
Science Times
PNAS: Benjamin Becker's team reveals microscopic transcriptional signatures of angiotensin type II1 receptor-associated reward processing
*：bioartmed
Recently, a study combined the whole brain gene expression map, metacognitive analysis method and pharmacological functional magnetic resonance imaging technology based on randomized placebo-controlled experimental design to systematically characterize the structure and functional correlation of AT1R, providing the underlying biological explanation framework of the cognitive process of AT1R association reward processing and improving the possibility of its clinical translation.
PLOS BIOL: Challenge the norm! The inhibitory neurotransmitter aminobutyric acid also plays a role in activating neurons
*: Bioon cells.
In a new study, researchers have found that a neurotransmitter previously thought to only tranquil neurons may also play a role in waking up neurons, a finding that challenges textbook ideas about how neurons communicate with each other in the brain.
Nature Sub-Journal:Researchers have found possible solutions to reverse the effects of Alzheimer's disease
*: Alzheimer's disease.
A new study** published recently reveals breakthrough structural details of how diseases similar to Alzheimer's disease (AD) develop. With this knowledge, the research team may have discovered a unique mechanism that could reverse these deposits and their effects on patients with these diseases.
The researchers found that the N-terminal domain of the peptide is important for programming the assembly shape, while the C-terminal modification directs left- or right-hand within the material. Using these design rules, a series of peptides switch between left- and right-handed twisted bands as needed depending on temperature changes. This reversal of the torsion makes the material susceptible to degradation by native proteins, which is an ideal feature of the material used as a delivery vehicle.
Nature: The Future of Thought Control: A Breakthrough in Brain-Computer Connectivity
*: Biological exploration.
Brain-Computer Interface (BCI) technology is a revolutionary technological advancement that opens a new chapter in the exploration of the secrets of the brain by directly connecting the brain to external devices. This technology is not only expected to provide more autonomy for people with disabilities, but also provides scientists with a unique way to study how the brain processes information, controls movement, and produces language. Recently, the journal Nature discussed the latest developments in this field.
psychoradiology ：Potential role of brain evoked potentials in psychiatric disorders**
*: Psychiatric imaging.
Repetitive ERP screening of patients to guide neurocognition**With the rapid development of brain imaging or electrophysiology techniques, it is possible to analyze normal and pathological behaviors using specific patterns of distributed neural activity. Among these techniques, electroencephalography (EEG) and its derived event-related potentials (ERPs) are widely used. Recently, researchers have proposed specific directions for the work of brain evoked potentials in psychiatric disorders**.
, brain communications: SingSong helps with stroke**
*: BME** Engineering Branch.
About 40% of stroke survivors develop aphasia, a difficulty in understanding or expressing spoken or written language caused by accidental cerebrovascular injury. Half of these patients have a communication impairment 1 year after the stroke. Aphasia has a wide-ranging impact on the functioning and quality of life of stroke survivors and predisposes to social isolation. It is a multi-purpose and effective tool to support motor, cognitive, and emotional recovery after stroke, but has not been effectively used to date in the clinical setting of chronic aphasia after stroke. A recent study showed that singing-based groups** could enhance communication and verbal expression in patients, as well as increase social activity, even in the chronic phase of stroke. The burden on family carers participating in the study was also significantly reduced.
displays：Quantitative evaluation of VR motion sickness based on EEG signals and CNN-ECA-LSTM network
*: Brain-computer interface community.
In this study, different degrees of motion sickness were induced by the visual stimulation paradigm, and the corresponding EEG data were collected. The spatiotemporal characteristics of EEG signals were extracted through spatiotemporal convolution, and the temporal context and dynamic change characteristics of motion sickness were fully utilized, and the dependence of EEG on the timing series was extracted by LSTM, and finally the CNN-ECA-LSTM Network (CELNET) was proposed to decode the EEG data to obtain the score of motion sickness.
, SCI ADV: Synaptic Electronics - Reconfigurable analog operator that integrates long-term and short-term synapses
**: West Wearable Electronics.
Implementing flexible analog operators by selectively defining short-term synapses (STS) and long-term synapses (LTS) to extract valuable information from spillover data is a critical but challenging task. Processing large amounts of biometric data requires a lot of computer resources and data specialists. The researchers presented the development of electrolyte-gated organic transistors with a selective transition from short-term to long-term plasticity of biological synapses. The memory behavior of synaptic devices is precisely modulated by the photochemical reaction of cross-linked molecules to restrict the penetration of ions through organic channels. In addition, the applicability of memory-controlled synaptic devices is verified by constructing reconfigurable synaptic logic gates to implement medical algorithms without the need for further weight update processes. Finally, the proposed neuromorphic device demonstrates the feasibility of processing biometric information with different update cycles and performing healthcare tasks.
Reviewer: Simon