ZFHX1B (Zinc Finger Homeobox Protein 1B) is an important transcription factor protein that is localized to 20Q13 in the human genome12。ZFHX1B is a macromolecular protein containing multiple domains, including multiple zinc finger domains and a homeobox domain. Its genes are made up of 14 introns and 15 exons, producing a protein that is about 235 kda long. ZFHX1B protein plays an important biological function by binding to DNA to regulate the transcriptional activity of genes.
Catalog No. PA1000-9102
ZFHX1B is mainly involved in gene regulation during embryonic development and organ formation. During embryonic development, ZFHX1B regulates the expression of multiple genes, including transcription factors and cell adhesion molecules. It plays an important role in the development of the nervous system and cardiovascular system, especially in the formation and function of brain neurons. In addition, ZFHX1B is also involved in the process of organ formation and is essential for growth and development.
The structure of ZFHX1B includes multiple zinc finger domains and a homeobox domain. The zinc finger domain is a common DNA-binding domain that regulates the expression of genes by binding to specific nucleotide sequences in DNA. The homeobox domain is a specific DNA-binding domain that is involved in the regulation of genes related to embryonic development and organ formation. Together, these domains allow ZFHX1B to bind to DNA and regulate gene expression, thereby fulfilling its important functions in embryonic development and organogenesis.
Overall, ZFHX1B is an important transcription factor protein that plays a key regulatory role in embryonic development and organogenesis. By binding to DNA to regulate gene expression, ZFHX1B is involved in the development of the nervous system, cardiovascular system, and other organs. The role of multiple functional domains together promotes ZFHX1B to exert its important biological functions. The in-depth study of ZFHX1B will help to further understand the molecular mechanisms of embryonic development and organ formation, and provide new ideas and methods for related diseases.