To determine whether exercise can increase plasma levels of factors that benefit brain health, the researchers equipped a portion of the cage with treadmills in which mice could run as much as they wanted every night — young mice the equivalent of 25 years old and capable of running 7 to 10 kilometers a night.
Plasma was collected and injected into the inactive young mice, and it was found that the proliferation rate and survival rate of hippocampal cells of young mice injected with ** exercise mouse plasma were significantly increased. This is similar to the effect observed in exercise mice, suggesting that exercise produces transferable anti-inflammatory factors. Note**After exercising the plasma of mice, the learning and memory of the environment and space were also enhanced. Proteomic analysis of these plasmas revealed that specific factors, such as clustered proteins, play a key role in anti-inflammatory effects.
It was also found that 20 patients with mild cognitive impairment experienced an increase in plasma clustered protein levels after 6 months of physical activity intervention.
The findings suggest that there may be transferable anti-inflammatory "motor factors" in plasma that are beneficial to the brain; The research also points to a new direction for the development of the most advanced means for diseases such as Alzheimer's disease.