Aspirin, the tiny white pill, has been with humanity for nearly a century. From the initial accidental discovery of antipyretic and analgesic effects, to the widespread use in the prevention of cardiovascular diseases and **, the legend of aspirin has left a strong mark in the history of medicine.
Aspirin, a seemingly ordinary name, contains a huge scientific mystery behind it. It was invented in 1897 by Bayer, a German pharmaceutical company, and after many studies and improvements, its unique pharmacological effects were gradually revealed.
The main component of aspirin is acetylsalicylic acid, which has the effect of inhibiting cyclooxygenase and thromboxane A2. This means that it not only relieves pain and reduces fever, but more importantly, it is able to effectively inhibit platelet aggregation, thereby reducing the risk of cardiovascular events such as myocardial infarction and cerebral infarction.
Aspirin is a drug with a long history and is widely used for various diseases. It can achieve pain relief and fever reduction by inhibiting the synthesis of cyclooxygenase and thromboxane A2. In addition, aspirin can also be used to prevent blood clots, thereby reducing the risk of cardiovascular diseases such as myocardial infarction and stroke.
In cardiovascular disease, aspirin can be used to prevent myocardial infarction and cerebral infarction**. Long-term use of aspirin can significantly reduce the risk of recurrence of myocardial infarction or cerebral infarction in patients who have already had a myocardial infarction or cerebral infarction. In addition, aspirin can also be used to prevent transient ischemic attacks, thereby reducing the risk of cerebral infarction.
When it comes to cancer, aspirin is also thought to have some preventive effect. Studies have shown that long-term use of aspirin can reduce the incidence of cancers such as colorectal cancer and gastric cancer. In addition, aspirin can also enhance the efficacy of certain chemotherapy drugs and improve the survival rate of cancer patients.
In arthritis, aspirin can be used to relieve pain and reduce inflammation. For chronic pain diseases such as rheumatoid arthritis and osteoarthritis, aspirin has some efficacy.
Overall, aspirin, as a commonly used drug, has a wide range of ** effects. However, long-term use of aspirin also has certain *** such as gastrointestinal bleeding and allergic reactions. Therefore, it is necessary to follow the doctor's advice when using aspirin and pay attention to controlling the dosage and duration of use.
Is aspirin, the hero in the prevention and treatment of cardiovascular diseases, really about to retire?The U.S. Prevention Task Force has suggested that people over 60 should not use aspirin as a means of primary prevention. Does this mean that its glory days are over?Aspirin, the pioneer of anti-platelet aggregation, works with the cyclooxygenase on platelets to effectively inhibit platelet aggregation, especially at the critical moment of plaque rupture, it stands up to block platelet aggregation and makes great achievements in reducing the risk of blood clots. However, aspirin is also a double-edged sword, as it reduces the risk of blood clots, but it can also cause bleeding concerns. Clinical studies have shown that diabetic patients who take aspirin have a reduction in vascular events, but a significant increase in complications. 
The U.S. Preventive Services Task Force has revisited the role of aspirin in cardiovascular primary prevention. They conducted a comprehensive assessment of cardiovascular mortality and risk of adverse events for the use of the new version of aspirin in people without a history of cardiovascular disease.
It was concluded that people aged 40 to 59 years with a 10-year risk of cardiovascular disease greater than 10% had little benefit from taking aspirin for primary prevention. Therefore, they do not recommend continued use of aspirin as a preventive strategy for cardiovascular disease in people over the age of 60.
It can be seen that although aspirin has indelible merits in the prevention and treatment of thrombosis, it is necessary to carefully consider the actual situation of the individual when choosing to use it. Gastrointestinal upset – Aspirin may cause gastrointestinal symptoms such as stomach pain, nausea, vomiting, and diarrhea.
Allergic reactions – Some people may experience allergic reactions such as rashes, asthma, difficulty breathing, etc.
Bleeding tendencies – Aspirin may increase the risk of bleeding, such as nosebleeds, bleeding gums, and bleeding from internal organs.
Liver damage – Long-term heavy use of aspirin may cause liver damage.
Kidney damage – Aspirin may cause damage to the kidneys, especially when used in large amounts for long periods of time.
Hearing impairment – Aspirin may affect hearing, causing tinnitus and hearing loss.
*Damage – Aspirin may cause symptoms such as rashes, hives, and itching.
Headache and dizziness – Aspirin may cause symptoms such as headache and vertigo.
When using aspirin, it is important to pay attention to these *** and take timely steps to prevent or reduce symptoms. At the same time, follow your doctor's advice and don't blindly use or stop taking the drug on your own. If you experience any symptoms of discomfort, you should seek medical attention promptly.
Allergic reactions
If any allergic reactions occur, such as rash, difficulty breathing, or swelling, aspirin should be stopped immediately.
Digestive problems
Aspirin may cause stomach upset, such as stomach pain, stomach bleeding, or stomach ulcers. If you experience these symptoms after using aspirin, you should stop using it immediately.
Bleeding problems
Aspirin may increase the risk of bleeding, including intracranial bleeding and bleeding at other sites. If you show signs of heavy bleeding after using aspirin, you should stop using it immediately.
Liver and kidney dysfunction
Aspirin is metabolized in the liver and kidneys, so for patients with liver and kidney dysfunction, the dose may need to be adjusted or discontinued.
Pregnant and lactating women
Pregnant and breastfeeding women should be cautious when taking aspirin as aspirin may cause adverse effects on the fetus and baby.
Other drug interactions
If you are taking other medications, especially anticoagulant drugs, warfarin, etc., concomitant use with aspirin may interact with it and lead to serious consequences.
In conclusion, if you experience any discomfort or abnormal reaction after using aspirin, you should stop using it immediately and consult your doctor's advice. Before using any medication, it is very important to know the *** and precautions of the medication.