CCR10 is a chemokine receptor that belongs to the chemokine receptor family. The encoding gene, located on human chromosome 17, is a transmembrane protein that contains a common characteristic structure of the epidermal chemokine receptor family. CCR10 frequently binds to two chemokine ligands, CCL27 and CCL28, and is involved in regulating immune cell motility and tissue-specific migration. Catalog No. PA1000-9372
CCR10 is widely distributed in a variety of tissues and cell types in the human body, and is mainly expressed on the surface of immune cells in tissues such as **, small intestine, lymph nodes, etc. In mucosal tissues such as ** and intestine, the expression level of CCR10 is high, which is mainly involved in the regulation of immune cell migration and inflammatory response in these tissues. In addition, CCR10 is also involved in regulating the differentiation and function of leukocytes in tissues such as ** and intestines, which is of great significance for maintaining immune balance and protection in tissues.
The structure of CCR10 protein mainly includes an N-terminal extracellular domain, seven transmembrane domains, and a C-terminal intracellular domain. This structural feature determines that CCR10 can specifically bind to extracellular signaling molecules and transmit signals through intracellular signal transduction pathways, ultimately affecting cell migration and function. After CCR10 binds to ligands, it can activate PI3K AKT, MAPK and other signaling pathways, causing cell migration, proliferation and cytokine production.
The functions of CCR10 mainly include promoting the migration and aggregation of immune cells to the area of inflammation foci, and enhancing the clearance of pathogens by immune cells. regulates the positioning and function of immune cells in tissues, and participates in the coordination of humoral immunity and cellular immunity; Regulates inflammatory response and tissue repair processes, protecting tissues from pathogen infection and external damage.
In conclusion, CCR10 is an important chemokine receptor, which is involved in the regulation of immune cell migration and function, and plays an important role in maintaining tissue immune balance and resisting external pathogens. Further study of the structure and functional mechanism of CCR10 will help deepen the understanding of immune regulation and disease occurrence and development, and provide new ideas and methods for disease prevention and prevention.